Transfusion and Apheresis Science
Volume 27, Issue 3 , Pages 199-202, December 2002

Circulating highly fluorescent reticulocytes to predict the adequate harvesting of peripheral blood progenitor cells in platinum-based chemotherapy

Department of Obstetrics and Gynecology, Faculty of Medicine, Niigata University, Asahimachi-dori 1-757, Niigata 951-8510, Japan

Received 18 January 2002; accepted 3 June 2002.

Abstract 

We prospectively evaluated whether peripheral blood progenitor cells (PBPC) yield from a single leukapheresis could be predicted by measurement of circulating highly fluorescent reticulocytes (HFR). PBPC were collected from 46 leukaphereses in 15 patients with gynecological cancer following platinum-based chemotherapy. Once a level of at least 5.0% HFR was achieved, sufficient PBPC were collected in a single harvest in 71% of the procedures. Whereas, failure to mobilize sufficient PBPC occurred in 24 of 28 leukaphereses when the percentage of circulating HFR was less than 5.0%. In conclusion, circulating HFR may aid in the efficiency of PBPC collections in platinum-based chemotherapy.

Keywords:  HFR, CFU-GM, CD34+ cells, PBPC, Platinum-based chemotherapy

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PII: S1473-0502(02)00065-4

Transfusion and Apheresis Science
Volume 27, Issue 3 , Pages 199-202, December 2002

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