Transfusion and Apheresis Science
Volume 30, Issue 1 , Pages 41-46 , February 2004

Universal leukodepletion of blood components results in a significant reduction of febrile non-hemolytic but not allergic transfusion reactions

  • Axel Pruss

      Affiliations

    • Institute for Transfusion Medicine (Tissue Bank), University Hospital Charité, Campus Charité Mitte, Schumannstrasse 20/21, D-10117 Berlin, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49-30-450-525161; fax: +49-30-450-525976
    • ,
  • Ulrich Kalus

      Affiliations

    • Institute for Transfusion Medicine (Tissue Bank), University Hospital Charité, Campus Charité Mitte, Schumannstrasse 20/21, D-10117 Berlin, Germany
    • ,
  • Hartmut Radtke

      Affiliations

    • Institute for Transfusion Medicine (Tissue Bank), University Hospital Charité, Campus Charité Mitte, Schumannstrasse 20/21, D-10117 Berlin, Germany
    • ,
  • Jürgen Koscielny

      Affiliations

    • Institute for Transfusion Medicine (Tissue Bank), University Hospital Charité, Campus Charité Mitte, Schumannstrasse 20/21, D-10117 Berlin, Germany
    • ,
  • Bärbel Baumann-Baretti

      Affiliations

    • Institute for Transfusion Medicine (Tissue Bank), University Hospital Charité, Campus Charité Mitte, Schumannstrasse 20/21, D-10117 Berlin, Germany
    • ,
  • Dominik Balzer

      Affiliations

    • Institute for Transfusion Medicine (Tissue Bank), University Hospital Charité, Campus Charité Mitte, Schumannstrasse 20/21, D-10117 Berlin, Germany
    • ,
  • Thomas Dörner

      Affiliations

    • Department of Medicine, Rheumatology and Clinical Immunology, University Hospital Charité, Humboldt University, D-10098 Berlin, Germany
    • ,
  • Abdulgabar Salama

      Affiliations

    • Institute for Transfusion Medicine (Tissue Bank), University Hospital Charité, Campus Charité Mitte, Schumannstrasse 20/21, D-10117 Berlin, Germany
    • ,
  • Holger Kiesewetter

      Affiliations

    • Institute for Transfusion Medicine (Tissue Bank), University Hospital Charité, Campus Charité Mitte, Schumannstrasse 20/21, D-10117 Berlin, Germany

Received 1 November 2002 ,Accepted 1 August 2003.

References 

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  2. Perkins HA, Payne R, Ferguson J, Wood M. Nonhemolytic febrile transfusion reactions. Vox Sang. 1966;11:578–600
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  16. Smit JJJ, de Vries AJ, Gu YJ, von Oeveren W. Efficiency and safety of leukocyte filtration during cardiopulmonary bypass for cardiac surgery. Transfus. Sci. 1999;20:151–165
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  19. Mangano MM, Chambers LA, Kruskall MS. Limited efficiacy of leukopoor platelets für prevention of febrile transfusion reactions. Am. J. Clin. Pathol. 1991;95:733–738
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  25. Goodnough LT, Riddell J, Lazarus H, Chafel TL, Prince GM, Hendrix D, et al.  Prevalence of platelet transfusion reactions before and after implementation of leukocyte-depleted platelet concentrates by filtration. Vox Sang. 1993;65:103–107
  26. Muir JC, Jacobson S, Herschel L, AuBuchon JP. Does pre-storage leukocyte reduction of blood components reduce the risk of febrile reactions in sensitized patients. Transfusion. 1994;Suppl-Abstract 1842:464a
  27. Dzieczkowski JS, Barrett BB, Nester D, Campbell M, Cook J, Sugrue M, et al.  Characterization of reactions after exclusive transfusion of white cell-reduced cellular blood components. Transfusion. 1995;35:20–25
  28. Federowicz I, Barrett BB, Andersen JW, Urashima M, Popovsky MA, Anderson KC. Characterization of reactions after transfusion of cellular blood components that are white cell reduced before storage. Transfusion. 1996;36:21–28
  29. Kelley DL, Mangini J, Lopez-Plaza I, Triulzi DJ. The utility of ⩽3-day-old whole-blood platelets in reducing the incidence of febrile nonhemolytic transfusion reactions. Transfusion. 2000;40:439–442
  30. Uhlmann EJ, Isgriggs E, Wallhermfechtel M, Goodnough LT. Prestorage universal WBC reduction of RBC units does not affect the incidence of transfusion reactions. Transfusion. 2001;41:997–1000
  31. Ibojie J, Greiss MA, Urbaniak SJ. Limited efficacy of universal leucodepletion in reducing the incidence of febrile nonhaemolytic reactions in red cell transfusions. Transfus. Med. 2002;12:181–185

PII: S1473-0502(03)00196-4

doi: 10.1016/j.transci.2003.08.013

Transfusion and Apheresis Science
Volume 30, Issue 1 , Pages 41-46 , February 2004

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