Tissue distribution of blood group membrane proteins beyond red cells: Evidence from cDNA libraries☆

Received 13 March 2006; accepted 19 May 2006.

Abstract

The proteins of blood group systems are expressed on red blood cells (RBC) by definition. We searched nucleotide databases of human expressed sequence tags (EST) to collate the distribution of 22 distinct membrane proteins in cells and tissues other than RBC. The documented blood group genes are: MNS, Rh, Lutheran, Kell, Duffy, Kidd, Diego, Yt, Xg, Scianna, Dombrock, Colton, Landsteiner-Wiener, Kx, Gerbich, Cromer, Knops, Indian, Ok, Raph, John–Milton–Hagen and Gill. The genes were grouped according to their overall and their relative expression in embryo and adults. We describe the distribution of EST in cells, tissues and cell lines with a focus on non-RBC tissues.

a Department of Transfusion Medicine, University Hospital Ulm, Germany

b Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, Germany

Corresponding author. Present address: Abteilung Transfusionsmedizin, Universitätsklinikum Ulm, Helmholtzstrasse 10, D-89081 Ulm, Germany. Tel.: +49 731 150 600; fax: +49 731 150 602.

☆ This work was supported by grants from the DRK-Blutspendedienst Baden-Württemberg – Hessen, Mannheim; and from the Deutsche Gesellschaft für Transfusionsmedizin und Immunhämatologie (Project DGTI/fle/0301).

PII: S1473-0502(06)00093-0

doi:10.1016/j.transci.2006.05.008

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