Effect of the ABO blood group on the proliferative and clonogenic capacity of umbilical cord stem cells

Galan, Isabel; Santolaya-Forgas, Joaquin; Leon, Juan De; Uhlmann, Rebecca A.; Montenegro, Daniel; Hume, Roderick; Mari, Giancarlo

doi:10.1016/j.transci.2006.05.012

« Previous Next »Transfusion and Apheresis Science
Volume 35, Issue 2 , Pages 119-123, October 2006

Effect of the ABO blood group on the proliferative and clonogenic capacity of umbilical cord stem cells

Isabel Galan
- Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Hutzel Women’s Hospital, Box #4, 3990 John R., Detroit, MI 48201, United States
Joaquin Santolaya-Forgas
- Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Hutzel Women’s Hospital, Box #4, 3990 John R., Detroit, MI 48201, United States
- Corresponding author. Tel.: +1 617 732 42 08; fax: +1 617 2646310.
Juan De Leon
- Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Hutzel Women’s Hospital, Box #4, 3990 John R., Detroit, MI 48201, United States
Rebecca A. Uhlmann
- Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Hutzel Women’s Hospital, Box #4, 3990 John R., Detroit, MI 48201, United States
Daniel Montenegro
- Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Hutzel Women’s Hospital, Box #4, 3990 John R., Detroit, MI 48201, United States
Roderick Hume
- Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Hutzel Women’s Hospital, Box #4, 3990 John R., Detroit, MI 48201, United States
Giancarlo Mari
- Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University, Hutzel Women’s Hospital, Box #4, 3990 John R., Detroit, MI 48201, United States

Received 4 January 2006; received in revised form 2 May 2006; accepted 25 May 2006.

Abstract

Possible effects of the ABO blood group on the proliferative and self-renewal capacity of umbilical cord CD34+ cells were evaluated. A, B and O (all Rh D+) CD34+ cells isolated from three placental blood samples were cultured in four platforms with hematopoietic growth factors on a 3-dimensional biocompatible matrix. Results from this study suggest that proliferation of CD34+ cells with the O phenotype may be greater than that of cells with the A or B phenotypes. Further ex vivo studies are required to confirm this finding and to determine the effect of the number and type of other genetically determined cell surface antigens on the capacity of hematopoietic stem cells to respond to cytokines. In addition, clinical studies aimed at determining if the CD34+ donor blood group affects the time to functional hematological reconstitution are recommended.