Transfusion and Apheresis Science
Volume 35, Issue 2 , Pages 137-143 , October 2006

Salvaging of liquid-preserved O-positive and O-negative red blood cells by rejuvenation and freezing

  • Gina Ragno
    • ,
  • C. Robert Valeri

      Affiliations

    • Corresponding Author InformationCorresponding author. Address: NBRL, Inc., 195 Bournehurst Drive, Plymouth, MA 02360, United States. Tel.: +1 508 747 4472; fax: +1 508 759 2317.
    web address

Received 27 June 2006 ,Accepted 2 July 2006.

References 

  1. Valeri CR, Zaroulis CG. Rejuvenation and freezing of outdated stored human red cells. NEJM. 1972;287:1307–1313
  2. Valeri CR, Valeri DA, Dennis RC, Vecchione JJ, Emerson CP. Biochemical modification and freeze-preservation of red blood cells. A new method. Crit Care Med. 1979;7:438–447
  3. Valeri CR. Status report on rejuvenation and freezing of red blood cells. Plasma Ther. 1981;2:155–170
  4. Valeri CR, Valeri DA, Anastasi J, Vecchione JJ, Dennis RC, Emerson CP. Freezing in the primary polyvinyl chloride plastic collection bag: a new system for preparing and freezing non-rejuvenated and rejuvenated red blood cells. Transfusion. 1981;21:138–149
  5. Valeri CR. Use of rejuvenation solutions in red blood cell preservation. Crit Rev Clin Lab Sci. 1982;17:299–374
  6. Brecher ME, Zylstra-Halling VW, Pineda AA. Rejuvenation of erythrocytes preserved with AS-1 and AS-3. Am J Clin Pathol. 1991;96:767–769
  7. Samuel LH, Anderson G, Mintz PD. Rejuvenation of irradiated AS-1 red cells. Transfusion. 1997;37:25–28
  8. Valeri CR, Pivacek LE, Cassidy GP, Ragno G. The survival, function, and hemolysis of human RBCs stored at 4°C in additive solution (AS-1, AS-3, or AS-5) for 42 days and then biochemically modified, frozen, thawed, washed and stored at 4°C in sodium chloride and glucose solution for 24 hours. Transfusion. 2000;40:1341–1345
  9. Lockwood WB, Hudgens RW, Szymanski IO, Teno RA, Gray AD. Effects of rejuvenation and frozen storage on 42-day old AS-3 RBCs. Transfusion. 2003;43:1527–1532
  10. Valeri CR, Ragno G, Pivacek LE, O’Neill EM. In vivo survival of apheresis RBCs, frozen with 40-percent (wt/vol) glycerol, deglycerolized in the ACP215, and stored at 4°C in AS-3 for up to 21 days. Transfusion. 2001;41:928–932
  11. Valeri CR, Ragno G, Pivacek LE, Srey R, Hess JR, Lippert LE, et al. A multicenter study of in vitro and in vivo values in human RBCs frozen with 40-percent (wt/vol) glycerol and stored after deglycerolization for 15 days at 4°C in AS-3: assessment of RBC processing in the ACP215. Transfusion. 2001;41:933–939
  12. Valeri CR, Srey R, Tilahun D, Ragno G. The in vitro quality of red blood cells frozen with 40% w/v glycerol at −80°C for 14 years, deglycerolized using the Haemonetics ACP215 and stored at 4°C in AS-1 or AS-3 for up to 3 weeks. Transfusion. 2004;44:990–995
  13. Valeri CR, Ragno G, Gennaoui A, Van Houten P, Rose L, Rose M, et al. Automation of the glycerolization of red blood cells with the high separation bowl in the Haemonetics ACP215 instrument. Transfusion. 2005;45:1621–1627
  14. Bandarenko N, Hay SN, Holmberg J, Whitley P, Taylor HL, Moroff G, et al. Extended storage of AS-1 and AS-3 leukoreduced red blood cells for 15 days after deglycerolization and resuspension in AS-3 using an automated closed system. Transfusion. 2004;44:1656–1662
  15. Blakney GB, Dinwoodie AJ. A spectrophotometric scanning technique for the rapid determination of plasma hemoglobin. Clin Biochem. 1975;8:96–102
  16. Runck AH, Valeri CR, Sampson WT. Comparison of the effects of ionic and non-ionic solutions on the volume and intracellular potassium of frozen and non-frozen human red cells. Transfusion. 1968;8:9–18
  17. Keitt AS. Pyruvate kinase deficiency and related disorders of red cell glycolysis. AM J Med. 1966;41:762–785
  18. Dennis RC, Bechthold D, Valeri CR. In vitro measurement of p50 – the pH correction and use of frozen red blood cells as controls. Crit Care Med. 1979;7:385–390
  19. Valeri CR, Szymanski IO, Zaroulis CG. 24-h survival of ACD- and CPD-stored red cells. I. Evaluation of nonwashed and washed stored red cells. Vox Sang. 1972;2:289–308
  20. Valeri CR, Valeri DA, Gray A, Melaragno AJ, Dennis RC, Emerson CP. Viability and function of red blood cell concentrates stored at 4°C for 35 days in CPDA-1, CPDA-2, or CPDA-3. Transfusion. 1982;22:210–216
  21. Valeri CR, Valeri DA, Gray A, Melaragno AJ, Dennis RC, Emerson CP. Red blood cell concentrates stored at 4°C for 35 days in CPDA-1, CPDA-2, or CPDA-3 anticoagulant-preservative, biochemically modified, and frozen and stored in the polyvinyl chloride plastic primary collection bag with 40% W/V glycerol at −80°C. Transfusion. 1982;22:102–106
  22. Gilcher RO, McComb S. Seasonal blood shortages can be eliminated. Curr Opin Hematol. 2005;12:503–508
  23. Hess JR. Blood use in war and disaster: the US experience. Presented at that 17th Annual Trauma and Anesthesia and Critical Care Symposium, Sydney, Australia, October 15–17, 2004, ITACCS; 2005. p. 7–13.

☆ The opinions or assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the Navy Department or Naval Service at large.

PII: S1473-0502(06)00113-3

doi: 10.1016/j.transci.2006.07.004

Transfusion and Apheresis Science
Volume 35, Issue 2 , Pages 137-143 , October 2006

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