Transfusion and Apheresis Science
Volume 35, Issue 2 , Pages 103-110 , October 2006

Heparin-mediated extracorporeal low density lipoprotein precipitation as a possible therapeutic approach in preeclampsia

  • Ying Wang

      Affiliations

    • Institute of Clinical Chemistry, University Hospital Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 89 7095 3239; fax: +49 7731 181112.
  • ,
  • Autar K. Walli

      Affiliations

    • Institute of Clinical Chemistry, University Hospital Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
  • ,
  • Andreas Schulze

      Affiliations

    • Division of Neonatology, Klinikum Grosshadern, University of Munich, Germany
  • ,
  • Frithjof Blessing

      Affiliations

    • Institute of Clinical Chemistry, University Hospital Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
  • ,
  • Peter Fraunberger

      Affiliations

    • Institute of Clinical Chemistry, University Hospital Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
  • ,
  • Christian Thaler

      Affiliations

    • Division of Obstetrics and Gynaecology, Klinikum Grosshadern, University of Munich, Germany
  • ,
  • Dietrich Seidel

      Affiliations

    • Institute of Clinical Chemistry, University Hospital Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
  • ,
  • Uwe Hasbargen

      Affiliations

    • Division of Obstetrics and Gynaecology, Klinikum Grosshadern, University of Munich, Germany

Received 3 November 2005 ,Revised 29 April 2006 ,Accepted 18 May 2006.

References 

  1. Sibai BM. Prevention of preeclampsia: a big disappointment. Am J Obstet Gynecol. 1998;179:1275–1278
  2. Antoinette CB, van Geijn HP, Gustaaf AD. Management and monitoring of severe preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2001;96:8–20
  3. Redman CWG, Sargent IL. Pre-eclampsia, the placenta and the maternal systemic inflammatory response – a review. Placenta. 2003;24:S21–S27
  4. Potter JM, Nestel PJ. The hyperlipidemia of pregnancy in normal and complicated pregnancies. Am J Obstet Gynecol. 1979;133:165–170
  5. Wang J, Mimuro S, Lahoud R, Trudinger B, Wang XL. Elevated levels of lipoprotein (a) in women with preeclampsia. Am J Obstet Gynecol. 1998;178:146–149
  6. Vince GS, Starkey PM, Austgulen R, Kwiatkowski D, Redman CWG. Interleukin-6, tumor necrosis factor and soluble tumor necrosis factor receptors in women with preeclampsia. Br J Obstet Gynaecol. 1995;102:20–25
  7. Heyl W, Handt S, Reister F, Gehlen J, Schröder W, Mittermayer C, et al. Elevated soluble adhesion molecules in women with pre-eclampsia: do cytokines like tumor necrosis factor-α and interleukin-1β cause endothelial activation?. Eur J Obstet Gynecol Reprod Biol. 1999;86:35–41
  8. Dechend R, Homuth V, Wallukat G, Kreuzer J, Park JK, Theuer J, et al. AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factor. Circulation. 2000;101:2382–2387
  9. Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med. 1998;338:1042–1050
  10. Seidel D, Armstrong VW, Schuff-Werner P for the HELP Study Group. The HELP-LDL-apheresis multicenter study, an angiographically assessed trial on the role of LDL-apheresis in the secondary prevention of coronary heart disease. I. Evaluation of safety and cholesterol-lowering effects during the first 12 months. Eur J Clin Invest. 1991;21:375–383
  11. Wang Y, Blessing F, Walli AK, Überfuhr P, Fraunberger P, Seidel D. Effects of heparin-mediated extracorporeal low-density lipoprotein precipitation beyond lowering proatherogenic lipoproteins – reduction of circulating proinflammatory and procoagulatory markers. Atherosclerosis. 2004;175:145–150
  12. Blessing F, Wang Y, Nagel D, Seidel D. The efficacy and safety of the new heparin-induced extracorporeal low-density lipoprotein precipitation system (Plasmat Futura) in comparison with the currently used system (Plasmat Secura). Ther Apher Dial. 2004;8:31–36
  13. Havel RJ. The abnormal lipoprotein of cholestasis. N Engl J Med. 1971;285:578–579
  14. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004;350:672–683
  15. Apstein CS, Zilversmit DB, Lees RS, George PK. Effect of intensive plasma-pheresis on the plasma cholesterol concentration with familial hyper-cholesterolemia. Atherosclerosis. 1978;31:105–115
  16. Armstrong VW, Schleef J, Thiery J, Muche R, Schuff-Werner P, Eisenhauer T, et al. Effect of HELP-LDL-apheresis on serum concentrations of human lipoprotein(a): kinetic analysis of the post-treatment return to baseline levels. Eur J Clin Invest. 1989;19:235–240
  17. Thiery J, Ivandic B, Bahlmann G, Walli AK, Seidel D. Hyperlipoprotein(a)-aemia in nephrotic syndrome. Eur J Clin Invest. 1996;26:316–321
  18. Brosens I, Robertson WB, Dixon HG. The role of the spiral arteries in the pathogenesis of pre-eclampsia. Obstet Gynecol Annu. 1972;1:177–191
  19. Caplice NM, Panetta C, Peterson TE, Klepper LS, Mueske CS, Kostner GM, et al. Lipoprotein (a) binds and inactivates tissue factor pathway inhibitor: a novel link between lipoproteins and thrombosis. Blood. 2001;98:2980–2987
  20. Sattar N, Bendomir A, Berry C, Shepherd J, et al. Lipoprotein subfraction concentrations in preeclampsia: pathogenic parallels to atherosclerosis. Obstet Gynecol. 1997;89:403–408
  21. Roberts JM, Pearson G, Cutler JA, Lindheimer MD. National Heart Lung and Blood Institute. Summary of the NHLBI working group on research on hypertension during pregnancy. Hypertens Pregnancy. 2003;22:109–127
  22. Metzger BE, Ravnikar V, Vileisis RA, Freinkel N. “Accelerated starvation” and the skipped breakfast in late normal pregnancy. Lancet. 1982;1:588–592
  23. Greer IA, Lyall F, Perera T, Boswell F, Macara LM. Increased concentrations of cytokines, interleukin-6 and interleukin-1 receptor antagonist in plasma of women with preeclampsia: a mechanism for endothelial dysfunction?. Obstet Gynecol. 1994;84:937–940
  24. Schuff-Werner P, Schutz E, Seyde WC, Eisenhauer T, Janning G, Armstrong VW, et al. Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin-induced extracorporeal LDL precipitation (HELP). Eur J Clin Invest. 1989;19:30–37
  25. Lee SK, McMillan DD, Ohlsson A, Pendray M, Synnes A, Whyte R, et al. Variations in practice and outcomes in the Canadian NICU network: 1996–1997. Pediatrics. 2000;106:1070–1079
  26. Kroon AA, Swinkels DW, van Dongen PWJ, Stalenhoef AFH. Pregnancy in a patient with homozygous familial hypercholeterolemia treated with long-term low density lipoprotein apheresis. Metabolism. 1994;43:1164–1170
  27. Teruel JL, Lasuncion MA, Navarro JF, Carrero P, Ortuno J. Pregnancy in a patient with homozygous familial hypercholesterolemia undergoing low-density lipoprotein apheresis by dextran sulfate adsorption. Metabolism. 1995;44:929–933
  28. Cashin-Hemphill L, Noone M, Abbott JF, Waksmonski CA, Lees RS. Low-density lipoprotein apheresis therapy during pregnancy. Am J Cardiol. 2000;86:1160

PII: S1473-0502(06)00115-7

doi: 10.1016/j.transci.2006.05.010

Transfusion and Apheresis Science
Volume 35, Issue 2 , Pages 103-110 , October 2006