Transfusion and Apheresis Science
Volume 41, Issue 3 , Pages 165-169 , December 2009

The effect of blood donation frequency on iron status

  • A.S. Røsvik

      Affiliations

    • Institute of Medicine, University of Bergen, Bergen, Norway
    • Institute of Life Sciences, Ålesund University College, Ålesund, Norway
    • Blood Bank, Haukeland University Hospital, Bergen, Norway
    • Corresponding Author InformationCorresponding author. Address: Institute of Life Sciences, Ålesund University College, N-6025 Ålesund, Norway. Tel.: +47 70 16 14 62; fax: +47 70 16 13 00.
    • ,
  • R.J. Ulvik

      Affiliations

    • Institute of Medicine, University of Bergen, Bergen, Norway
    • Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway
    • ,
  • T. Wentzel-Larsen

      Affiliations

    • Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway
    • ,
  • T. Hervig

      Affiliations

    • Blood Bank, Haukeland University Hospital, Bergen, Norway
    • Gades Institute, University of Bergen, Norway

References 

  1. Flesland Ø, Bergan T. Blood-transfusion in Norway. Statistics for 2005. The Norwegian Association of Immunology and Transfusion Medicine; 2006.
  2. Finch CA, Cook JD, Labbe RF, Culala M. Effect of blood donation on iron stores as evaluated by serum ferritin. Blood. 1977;50:441–447
  3. Brittenham GM, Klein HG, Kushner JP, Ajioka RS. Preserving the national blood supply. Hematology (Am Soc Hematol Educ Prog). 2001;422–432
  4. Simon TL, Garry PJ, Hooper EM. Iron stores in blood donors. Jama. 1981;245:2038–2043
  5. Farrugia A. Iron and blood donation – an under-recognised safety issue. Dev Biol (Basel). 2007;127:137–146
  6. Brittenham GM. Iron balance in the red blood cell donor. Dev Biol (Basel). 2005;120:77–82
  7. Boulton F. Managing donors and iron deficiency. Vox Sang. 2004;87(Suppl. 2):22–24
  8. Radtke H, Tegtmeier J, Rocker L, Salama A, Kiesewetter H. Daily doses of 20 mg of elemental iron compensate for iron loss in regular blood donors: a randomized, double-blind, placebo-controlled study. Transfusion. 2004;44:1427–1432
  9. Milman N, Kirchhoff M. Influence of blood donation on iron stores assessed by serum ferritin and haemoglobin in a population survey of 1433 Danish males. Eur J Haematol. 1991;47:134–139
  10. Milman N, Kirchhoff M. The influence of blood donation on iron stores assessed by serum ferritin and hemoglobin in a population survey of 1359 Danish women. Ann Hematol. 1991;63:27–32
  11. Punnonen K, Rajamäki A. Evaluation of iron status of Finnish blood donors using serum transferrin receptor. Trans Med (Oxford, England). 1999;9:131–134
  12. Punnonen K, Irjala K, Rajamäki A. Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood. 1997;89:1052–1057
  13. Røsvik AS, Hervig T, Wentzel-Larsen T, Ulvik RJ. Iron status in Norwegian blood donors: comparison of iron status in new blood donors registered in 1993–1997 and in 2005–2006. Vox Sang. 2009;96(1):49–55
  14. Directive 2002/98/EC of the European parliament and of the council of 27 January 2003 setting standards of quality and safety for the collection, testing, processing, storage and distribution of human blood and blood components and amending Directive 2001/83/EC.
  15. Venables WN, Smith DM, Team TRDC. An introduction to R. Vienna, Austria: R Foundation for Statistical Computing; 2008;
  16. Pinheiro JC, Bates DM. Mixed effects model in S and S-plus. New York: Springer; 2000;
  17. Magnussen K, Bork N, Asmussen L. The effect of a standardized protocol for iron supplementation to blood donors low in hemoglobin concentration. Transfusion. 2008;48:749–754
  18. Alexander HD, Sherlock JP, Bharucha C. Red cell indices as predictors of iron depletion in blood donors. Clin Lab Haematol. 2000;22:253–258
  19. Milman N, Sondergaard M, Sorensen CM. Iron stores in female blood donors evaluated by serum ferritin. Blut. 1985;51:337–345
  20. Skikne B, Lynch S, Borek D, Cook J. Iron and blood donation. Clin Haematol. 1984;13:271–287
  21. Skikne BS. Serum transferrin receptor. Am J Hematol. 2008;83:872–875
  22. Boulton F, Collis D, Inskip H, Paes H, Garlick M. A study of the iron and HFE status of blood donors, including a group who failed the initial screen for anaemia. Br J Haematol. 2000;108:434–439
  23. Worwood M, Darke C. Serum ferritin, blood donation, iron stores and haemochromatosis. Trans Med (Oxford, England). 1993;3:21–28

PII: S1473-0502(09)00137-2

doi: 10.1016/j.transci.2009.09.017

Transfusion and Apheresis Science
Volume 41, Issue 3 , Pages 165-169 , December 2009

Article Tools

* Image Usage & Resolution