The first results demonstrating efficiency and safety of a double-column whole blood method of LDL-apheresis
Abstract
LDL-apheresis is a treatment for familial hypercholesterolemia in addition to diet and drug therapy. In the past, LDL-apheresis techniques consisted in separating plasma from blood and adsorbing plasma LDL-C whereas recent methods remove LDL-C directly from whole blood. The whole blood system developed by Kaneka consists of a single-column (Liposorber DL-75) treatment (SCWB) but a double-column whole blood (DCWB) method has recently been developed (Liposorber DL-50
×
2).
When 1.6 blood volumes (plus 1
l) were processed, acute reductions of total cholesterol and LDL-C were 67.9
±
6% and 80.2
±
4.5%, respectively. The performances of the DCWB method were compared to other LDL-apheresis methods. Assessed in 10 patients, the DCWB method is more efficient than the SCWB method with higher reduction rates of LDL-C (79.7
±
4.9 vs. 68.2
±
5.0% p
<
0.0001) and apolipoprotein-B (79.5
±
5.4 vs. 67.4
±
5.4% p
<
0.0001). In a sub group of five patients having the highest LDL-C baseline levels, the LDL-C reduction rates obtained by the DCWB method are equivalent to those obtained by the conventional LDL-apheresis method consisting of preliminary plasma separation followed by plasma LDL-C adsorption and used as first line apheresis therapy (80.5
±
4.5 vs. 79.0
±
5.9%). The safety of DCWB was demonstrated in 12 patients with only a low frequency of mild and transient adverse effects (4%).
In conclusion, the DCWB LDL-apheresis method provides efficient removal of LDL-C, a low level of adverse effects, and a shortened duration of the procedure.
Keywords: LDL-apheresis, Whole Blood method, Adsorption of lipoproteins, LDL-C
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PII: S1473-0502(09)00169-4
doi:10.1016/j.transci.2009.10.001
© 2009 Elsevier Ltd. All rights reserved.
