Transfusion and Apheresis Science
Volume 42, Issue 1 , Pages 3-10 , February 2010

The first results demonstrating efficiency and safety of a double-column whole blood method of LDL-apheresis

  • O. Hequet

      Affiliations

    • Apheresis Unit, EFS (Etablissement Français du Sang), Hôpital Edouard Herriot, Lyon, France
    • Corresponding Author InformationCorresponding author. Address: Centre de santé, Etablissement Français du Sang (EFS), Pavillon I, Hospital Edouard Herriot, 5 place d’Arsonval, 69003 Lyon, France. Tel.: +33 4 72 68 46 39; fax: +33 4 72 68 46 40.
    • ,
  • Q.H. Le

      Affiliations

    • Department of Biostatistics, Centre Hospitalier Lyon Sud, HCL (Hospices Civils de Lyon), Pierre Bénite, France
    • ,
  • D. Rigal

      Affiliations

    • Apheresis Unit, EFS (Etablissement Français du Sang), Hôpital Edouard Herriot, Lyon, France
    • ,
  • F. Mekhloufi

      Affiliations

    • Apheresis Unit, EFS (Etablissement Français du Sang), Hôpital Edouard Herriot, Lyon, France
    • ,
  • S. Jaeger

      Affiliations

    • Apheresis Unit, EFS (Etablissement Français du Sang), Hôpital Edouard Herriot, Lyon, France
    • ,
  • A. Sassolas

      Affiliations

    • Laboratory of Lipids, Hôpital Cardiologique, HCL Bron, France
    • ,
  • L. Groisne

      Affiliations

    • Endocrinology Unit, Hôpital Cardiologique, HCL, Bron, France
    • ,
  • P. Moulin

      Affiliations

    • Endocrinology Unit, Hôpital Cardiologique, HCL, Bron, France

Received 27 October 2008 ,Accepted 25 August 2009.

References 

  1. Tatami R, Inoue N, Itoh H, Kishino B, Koga N, Nakashima Y, et al. For the LARS investigators. Regression of coronary atherosclerosis by combined LDL-apheresis and lipid lowering drug therapy in patients with familial hypercholesterolemia: a multicenter study. Atherosclerosis. 1992;95:1–13
  2. Palcoux JB, Meyer M, Jouanel P, Tridon A, Vanlieferinghen P, Carla H, et al. Treatment of homozygous familial hypercholesterolemia by plasma exchange and LDL-apheresis. Transf Sci. 1993;14:423–427
  3. Thompson GR, Maher VM, Matthews S, Kitano Y, Neuwirth C, Shortt MB, et al. Familial hypercholesterolaemia regression study: a randomised trial of low-density-lipoprotein apheresis. Lancet. 1995;345:811–816
  4. Otto C, Kern P, Bambauer R, Kallert S, Schwandt P, Parhofer KG. Efficacy and safety of a new whole-blood low-density-lipoprotein apheresis system (Liposorber D) in severe hypercholesterolemia. Artif Organs. 2003;27:1116–1122
  5. Bosch T, Schmidt B, Kleophas W, Gillen C, Otto V, Passlick-Deetjen J, et al. LDL hemoperfusion – a new procedure for LDL apheresis: first application of an LDL adsorber compatible with human whole blood. Artif Organs. 1997;21:977–982
  6. Dräger LJ, Julius U, Kraenzle K, Schaper J, Toepfer M, Zygan K, et al. DALI – the first human whole-blood low-density-lipoprotein and lipoprotein(a) apheresis system in clinical use: procedure and clinical results. Eur J Clin Invest. 1998;28:994–1002
  7. Kobayashi A, Nakatami M, Furuyoshi S, Tani N. In vitro evaluation of dextran sulfate cellulose beads for whole blood infusion low-density lipoprotein–hemoperfusion. Ther Aph. 2002;6:365–371
  8. Archontakis S, Pottle A, Hakim N, Ilsley C, Barbir M. LDL-apheresis: indications and clinical experience in a tertiary cardiac centre. Int J Clin Pract. 2007;61:1834–1842
  9. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-lensity lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502
  10. Pineiro JC, Bates DM. Mixed effects models in S and S-plus. Springer-Verlag; 2000.
  11. Wendler T, Schilling R, Lennertz A, Sodemann K, Kleophas W, Messner H, et al. Efficacy and safety of DALI LDL-apheresis at high blood flow rates: a prospective multicenter study. J Clin Aph. 2003;18:157–166
  12. Kontush A, Chapman J. Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis. Pharmacol Rev. 2006;58:342–374
  13. Opole IO, Belmont JM, Kumar A, Moriarty PM. Effect of a low-density lipoprotein apheresis on inflammatory and noninflammatory high-density lipoprotein cholesterol. Am J Cardiol. 2007;100:1416–1418
  14. Bayrakci US, Besbas N, Ozcebe O, Coskun T, Akgul E, Kutluk T, et al. Direct adsorption of lipoproteins from whole blood by direct adsorption of lipoprotein apheresis: first experience in two hypercholesterolemic children. Ther Apher Dial. 2005;9:469–472
  15. Gordon BR, Kelsey SF, Dau PC, Gotto AM, Graham K, Illingworth DR, et al. Long-term effects of low-density lipoprotein apheresis using an automated dextran sulphate cellulose adsorption system. Liposorber Study Group. Am J Cardiol. 1998;81:407–411
  16. Bosch T, Gahr S, Belschner U, Schaefer C, Lennertz A, Rammo J. For the DALI Study Group. Direct adsorption of low-density lipoprotein by DALI-LDL-apheresis: results of a prospective long-term multicenter follow-up covering 12, 291 sessions. Ther Apher Dial. 2006;10:210–218

PII: S1473-0502(09)00169-4

doi: 10.1016/j.transci.2009.10.001

Transfusion and Apheresis Science
Volume 42, Issue 1 , Pages 3-10 , February 2010

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