Transfusion and Apheresis Science
Volume 42, Issue 1 , Pages 33-37, February 2010

Activation of fibrinolysis by reinfusion of unwashed salvaged blood after total knee arthroplasty

  • Keiji Matsuda

      Affiliations

    • Department of Orthopaedics, Juntendo Nerima Hospital, Tokyo, Japan
    • Corresponding Author InformationCorresponding author. Address: Department of Orthopaedics, Juntendo University Nerima Hospital, 3-1-10 Takanodai, Nerima-ku, Tokyo 177-8521, Japan. Tel.: +81 3 5923 3111; fax: +81 3 5923 3217.
    • ,
  • Masahiko Nozawa

      Affiliations

    • Department of Orthopaedics, Juntendo Nerima Hospital, Tokyo, Japan
    • ,
  • Sadanobu Katsube

      Affiliations

    • Department of Orthopaedics, Nakaizu Spa Hospital, Shizuoka, Japan
    • ,
  • Katsuhiko Maezawa

      Affiliations

    • Department of Orthopaedics, Juntendo University School of Medicine, Tokyo, Japan
    • ,
  • Hisashi Kurosawa

      Affiliations

    • Department of Orthopaedics, Juntendo University School of Medicine, Tokyo, Japan

Received 22 October 2008; received in revised form 12 November 2008; accepted 8 December 2008.

Abstract 

In 19 patients with RA and 20 with OA who underwent autotransfusion with unwashed salvaged blood (USB) after total knee arthroplasty, we performed serial measurement of D-dimer, FgDP, t-PA, and PIC in the plasma and salvaged blood. The PIC level at the completion of salvaged blood transfusion was closely correlated with the volume of USB reinfused in the RA group (p<0.001). The t-PA level of salvaged blood showed a significant positive correlation with the total volume of postoperative drainage in both the RA and OA groups (p<0.05). The increase of total postoperative drainage associated with reinfusion of USB is largely caused by an increase of t-PA in the salvaged blood.

Keywords: Autotransfusion, Unwashed salvaged blood, Total knee arthroplasty

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PII: S1473-0502(09)00173-6

doi:10.1016/j.transci.2009.10.005

Transfusion and Apheresis Science
Volume 42, Issue 1 , Pages 33-37, February 2010

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