Transfusion and Apheresis Science
Volume 42, Issue 2 , Pages 117-124 , April 2010

New method to produce hemocomponents for regenerative use from peripheral blood: Integration among platelet growth factors monocytes and stem cells

  • Gaetano Caloprisco

      Affiliations

    • Dipartimento di Immunoematologia e Medicina Trasfusionale, Ospedale San Martino, viale Europa 22, 32100 Belluno, Italy
    • Corresponding Author InformationCorresponding authors. Tel.: +39 0437 516297x516274; fax: +39 0437 516567 (G. Caloprisco), tel.: +39 0437 516274; fax: +39 0437 516567 (V. Borean).
    • ,
  • Alessio Borean

      Affiliations

    • Dipartimento di Immunoematologia e Medicina Trasfusionale, Ospedale San Martino, viale Europa 22, 32100 Belluno, Italy
    • Corresponding Author InformationCorresponding authors. Tel.: +39 0437 516297x516274; fax: +39 0437 516567 (G. Caloprisco), tel.: +39 0437 516274; fax: +39 0437 516567 (V. Borean).
    • ,
  • Sergio De Angeli

      Affiliations

    • Dipartimento di Immunoematologia e Medicina Trasfusionale, Ospedale Ca’ Foncello, Treviso, Italy
    • ,
  • Giovanni Battista Gaio

      Affiliations

    • Dipartimento di Immunoematologia e Medicina Trasfusionale, Ospedale Ca’ Foncello, Treviso, Italy
    • ,
  • Katia Boito

      Affiliations

    • Dipartimento di Immunoematologia e Medicina Trasfusionale, Ospedale Ca’ Foncello, Treviso, Italy
    • ,
  • Laura Del Pup

      Affiliations

    • Dipartimento di Immunoematologia e Medicina Trasfusionale, Ospedale Ca’ Foncello, Treviso, Italy
    • ,
  • Elisabetta Pavan

      Affiliations

    • Dipartimento di Immunoematologia e Medicina Trasfusionale, Ospedale Ca’ Foncello, Treviso, Italy
    • ,
  • Valentina Casale

      Affiliations

    • Dipartimento di Immunoematologia e Medicina Trasfusionale, Ospedale Ca’ Foncello, Treviso, Italy
    • ,
  • Ivone Varinelli

      Affiliations

    • Haemonetics Italia, Italy

References 

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  3. Grageda E, Lozada JL, Boyne PJ, et al. Bone formation in the maxillary sinus by using platelet rich plasma: an experimental study in sheep. J Oral Implantol. 2005;31:2–17
  4. Weibrich G, Hansen T, Kleis W, et al. Effect of platelet concentration in platelet-rich plasma on peri-implant bon regeneration. Bone. 2004;34:665–671
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  6. Caloprisco G, Barbone E, Borean A, et al. Local haemotherapy of chronic skin ulcers with leukocyte–platelet gel produced from blood components obtained with a cell separator. Blood Transfus. 2004;2:44–54
  7. Caloprisco G, Borean A. Chronic skin ulcers: a regenerative stimulation by topical haemotherapy. Int J Artif Organs. 2004;27:816–817
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  13. Danon D, Kovatch MA, Roth GS. Promotion of wound repair in old mice by local injection of monocytes/macrophages. Proc Natl Acad Sci USA Med Sci. 1989;86:2018–2020
  14. Zulaf-Shani A, Kachel E, Frenkel O, et al. Macrophage suspensions prepared from a blood unit for treatment of refractory human ulcers. Transfus Apher Sci. 2004;30:163–167
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  17. Kasten P, Vogel J, Luginbuhl R, et al. Influence of platelet-rich plasma on osteogenic differentiation of mesenchymal stem cells and ectopic bone formation in calcium phosphate ceramics. Cells Tissues Organs. 2006;183:68–79
  18. Kocaoemer A, Kern S, Kluter H, et al. Human AB serum and thrombin-activated platelet-rich plasma are suitable alternatives to fetal calf serum for the expansion of mesenchymal stem cells from adipose tissue. Stem cells. 2007;24:1270–1278
  19. Matsumoto T, Kawamoto A, Kuroda R, et al. Therapautic potential of vasculogenesis and osteogenesis promoted by peripheral blood CD34-positive cells for functional bone healing. AJP. 2006;169:1440–1457
  20. Tei K, Matsumoto T, Mifune Y, et al. Administrations of peripheral blood CD34-positive cells contribuite to medial collateral ligament healing via vasculogenesis. Stem Cells. 2008;26:819–830
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  22. Sivan-Loukianova E, Awad OA, Stepanovic V, et al. CD34+ blood cells accelarate vascularization and healing of diabetic mouse skin wounds. J Vasc Res. 2003;40:368–377
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  25. Galmes A, Besalduch J, Matamoros J, et al. Cryopreservation of hematopoietic progenitor cells with 5-percent dimethyl sulfoxide at −80°C without rate-controlled freezing. Transfusion. 1996;36:794–797
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  29. Christman KL, Vardanian AJ, Fang Q, et al. Injectable fibrin scaffold improves cell transplant survival, reduces infarct expansion, and induces neovascolature formation in ischemic myocardium. J Am Coll Cardiol. 2004;44:654–660
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  31. Urbich C, Heeschen C, Aicher A, et al. Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells. Circulation. 2003;108:2511–2516

PII: S1473-0502(10)00004-2

doi: 10.1016/j.transci.2010.01.003

Transfusion and Apheresis Science
Volume 42, Issue 2 , Pages 117-124 , April 2010

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