Transfusion and Apheresis Science
Volume 42, Issue 3 , Pages 283-288 , June 2010

The impact of immunogenetics and clinical factors on the outcome of unrelated cord blood transplantation: The Milano Cord Blood Bank data

  • Marta Serafini

      Affiliations

    • Organ and Tissue Transplantation Immunology, Foundation Ca’ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    • Corresponding Author InformationCorresponding author.
    • ,
  • Francesca Poli

      Affiliations

    • Organ and Tissue Transplantation Immunology, Foundation Ca’ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    • ,
  • Rosanna Torelli

      Affiliations

    • Organ and Tissue Transplantation Immunology, Foundation Ca’ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    • ,
  • Katharina Fleischhauer

      Affiliations

    • HLA Tissue Typing Laboratory and Immunohematology and Transfusion Medicine Service, Istituto di Ricovero e Cura a Carattere Scientifico, Hospital San Raffaele, Milan, Italy
    • ,
  • Elisabetta Zino

      Affiliations

    • HLA Tissue Typing Laboratory and Immunohematology and Transfusion Medicine Service, Istituto di Ricovero e Cura a Carattere Scientifico, Hospital San Raffaele, Milan, Italy
    • ,
  • Alejandro Espadas de Arias

      Affiliations

    • Organ and Tissue Transplantation Immunology, Foundation Ca’ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    • ,
  • Elena Longhi

      Affiliations

    • Organ and Tissue Transplantation Immunology, Foundation Ca’ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    • ,
  • Sara Frison

      Affiliations

    • Organ and Tissue Transplantation Immunology, Foundation Ca’ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    • ,
  • Katherina Karpasitou

      Affiliations

    • Organ and Tissue Transplantation Immunology, Foundation Ca’ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    • ,
  • Ilaria Pezzali

      Affiliations

    • Center of Transfusion Medicine, Cellular Therapy and Cryobiology, Foundation Ca’ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    • ,
  • Lucilla Lecchi

      Affiliations

    • Center of Transfusion Medicine, Cellular Therapy and Cryobiology, Foundation Ca’ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy
    • ,
  • Mario Scalamogna

      Affiliations

    • Organ and Tissue Transplantation Immunology, Foundation Ca’ Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122 Milan, Italy

References 

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  2. Brand A, Rebulla P, Engelfriet CP, Reesink HW, Beguin Y, Baudoux E, et al. Cord blood banking. Vox Sang. 2008;95:335–348
  3. Gluckman E, Rocha V. History of the clinical use of umbilical cord blood hematopoietic cells. Cytotherapy. 2005;7:219–227
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  8. Petersdorf EW, Anasetti C, Martin PJ, Gooley T, Radich J, Malkki M, et al. Limits of HLA mismatching in unrelated hematopoietic cell transplantation. Blood. 2004;104:2976–2980
  9. Hansen JA, Petersdorf EW, Lin MT, Wang S, Chien JW, Storer B, et al. Genetics of allogeneic hematopoietic cell transplantation. Role of HLA matching, functional variation in immune response genes. Immunol Res. 2008;41:56–78
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  11. Petersdorf EW, Gooley TA, Anasetti C, Martin PJ, Smith AG, Mickelson EM, et al. Optimizing outcome after unrelated marrow transplantation by comprehensive matching of HLA class I and II alleles in the donor and recipient. Blood. 1998;92:3515–3520
  12. Flomenberg N, Baxter-Lowe LA, Confer D, Fernandez-Vina M, Filipovich A, Horowitz M, et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood. 2004;104:1923–1930
  13. Gluckman E, Rocha V. Donor selection for unrelated cord blood transplants. Curr Opin Immunol. 2006;18:565–570
  14. Eapen M, Rubinstein P, Zhang MJ, Stevens C, Kurtzberg J, Scaradavou A, et al. Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet. 2007;369:1947–1954
  15. van Heeckeren WJ, Fanning LR, Meyerson HJ, Fu P, Lazarus HM, Cooper BW, et al. Influence of human leucocyte antigen disparity and graft lymphocytes on allogeneic engraftment and survival after umbilical cord blood transplant in adults. Br J Haematol. 2007;139:464–474
  16. Leung W, Iyengar R, Turner V, Lang P, Bader P, Conn P, et al. Determinants of antileukemia effects of allogeneic NK cells. J Immunol. 2004;172:644–650
  17. La Nasa G, Littera R, Locatelli F, Giardini C, Ventrella A, Mulargia M, et al. Status of donor–recipient HLA class I ligands and not the KIR genotype is predictive for the outcome of unrelated hematopoietic stem cell transplantation in beta-thalassemia patients. Biol Blood Marrow Transplant. 2007;13:1358–1368
  18. Fischer JC, Ottinger H, Ferencik S, Sribar M, Punzel M, Beelen DW, et al. Relevance of C1 and C2 epitopes for hemopoietic stem cell transplantation: role for sequential acquisition of HLA-C-specific inhibitory killer Ig-like receptor. J Immunol. 2007;15(178):2319–3918
  19. Boyington JC, Sun PD. A structural perspective on MHC class I recognition by killer cell immunoglobulin-like receptors. Mol Immunol. 2002;38:1007–1021
  20. Vivier E, Tomasello E, Baratin M, Walzer T, Ugolini S. Functions of natural killer cells. Nat Immunol. 2008;9:503–510
  21. Lanier LL. NK cell receptors. Annu Rev Immunol. 1998;16:359–393
  22. Cooley S, McCullar V, Wangen R, Bergemann TL, Spellman S, Weisdorf DJ, et al. KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor transplantation. Blood. 2005;106:4370–4376
  23. De Santis D, Bishara A, Witt CS, Nagler A, Brautbar C, Slavin S, et al. Natural killer cell HLA-C epitopes and killer cell immunoglobulin-like receptors both influence outcome of mismatched unrelated donor bone marrow transplants. Tissue Antigens. 2005;65:519–528
  24. Claas FH, Oudshoorn M. Role of NK cells in mismatched unrelated haematopoietic stem-cell transplantation: fact or fiction?. Tissue Antigens. 2005;65:515–518
  25. Willemze R, Rodrigues CA, Labopin M, Sanz G, Michel G, Socié G, et al. Eurocord-Netcord and Acute Leukaemia Working Party of the EBMT. KIR-ligand incompatibility in the graft-versus-host direction improves outcomes after umbilical cord blood transplantation for acute leukemia. Leukemia. 2009;23:492-500. .
  26. Brunstein CG, Wagner JE, Weisdorf DJ, Cooley S, Noreen H, Barker JN, et al. Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity. Blood. 2009;113:5628–5634
  27. Lee SJ, Kamani N, Confer DL. Principles and tools for selection of umbilical cord blood and unrelated adult donor grafts. Biol Blood Marrow Transplant. 2008;14(Suppl. 1):112–119
  28. Locatelli F, Rocha V, Chastang C, Arcese W, Michel G, Abecasis M, et al. Factors associated with outcome after cord blood transplantation in children with acute leukemia. Eurocord–Cord Blood Transplant Group. Blood. 1999;93:3662–3671
  29. Sirchia G, Rebulla P. Placental/umbilical cord blood transplantation. Haematologica. 1999;84:738–747

PII: S1473-0502(10)00059-5

doi: 10.1016/j.transci.2010.03.007

Transfusion and Apheresis Science
Volume 42, Issue 3 , Pages 283-288 , June 2010

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