Transfusion and Apheresis Science
Volume 42, Issue 3 , Pages 223-233 , June 2010

An approach to prevent the severe adverse events associated with transfusion of FDA-approved blood products

Received 5 June 2009 ,Accepted 10 August 2009.

References 

  1. Valeri CR, Ragno G. Cryopreservation of human blood products. Trans Apher Sci. 2006;34:271–287[with an editorial on p. 267–9]
  2. Lelkens CCM, Koning JR, deKort B, Floot IBG, Noorman F. Experience with frozen blood products in the Netherlands military. Trans Apher Sci. 2006;34:289–296
  3. Zimrin AB, Hess JR. Current issues relating to the transfusion of stored red blood cells. Vox Sang. 2009;96:93–103
  4. Lelubre C, Piagnerelli M, Vincent JL. Association between duration of storage of transfused red blood cells and morbidity and mortality in adult patients: myth or reality?. Transfusion. 2009;49:1384–1394
  5. Bennett-Guerrero E, Stafford-Smith M, Waweru PM, Bredehoeft S, Campbell ML, Haley NR, et al. A prospective, double-blind, randomized clinical feasibility trial of controlling the storage age of red blood cells for transfusion in cardiac surgical patients. Transfusion. 2009;49:1375–1383
  6. Steiner ME, Stowell C. Does red blood cells storage affect clinical outcome? When in doubt, do the experiment. Transfusion. 2009;49:1286–1290
  7. Basran S, Frumento RJ, Cohen A, Lee S, Du Y, Nishanian F, et al. The association between duration of storage of transfused red blood cells and morbidity and mortality after reoperative cardiac surgery. Anesth Analg. 2006;100:15–20
  8. Koch CG, Li L, Sessler DI, et al. Duration of red cell storage and complications after cardiac surgery. N Engl J Med. 2008;358:1229–1239
  9. Valeri CR. Measurement of viable ADSOL-preserved human red blood cells. N Eng J Med. 1985;312:377–378
  10. Valeri CR, Pivacek LE, Palter M, Dennis RC, Yeston N, Emerson CP, et al. A clinical experience with ADSOL® preserved erythrocytes. Surg Gynec Obstet. 1988;166:33–46
  11. Valeri CR. Status report on the quality of liquid and frozen red blood cells. Vox Sang. 2002;83(1):193–196
  12. McFaul SJ, Corley JB, Mester CW, Nath J. Packed blood cells stored in AS-5 become proinflammatory during storage. Transfusion. 2009;49:1451–1460
  13. Biffi WL, Moore EE, Offner PJ, Ciesla DJ, Gonzalez RJ, Silliman CC. Plasma from aged stored red blood cells delays neutrophil apoptosis and primes for cytotoxicity: abrogation by poststorage washing but not prestorage leukoreduction. J Trauma. 2001;50:426–432
  14. Adamson JW. Editorial new blood, old blood or no blood?. N Engl J Med. 2008;358:1295–1296
  15. Dzik W. Fresh blood for everyone? Balancing availability and quality of stored RBCs. Transfus Med. 2008;18:260–268
  16. Valeri CR. Physiology of blood transfusion. In:  Barie PS,  Shires GT editor. Surgical intensive care. Little, Brown & Co.; 1993;p. 681–721
  17. Maegele M, Lefering R, Paffrath T, Tjardes T, Simanski C, Bouillon B, et al. Red blood cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gessellschaft fur Unfallchirurgie. Vox Sang. 2008;95:112–119
  18. Hess JR, Dutton RB, Holcomb JB, Scalea TM. Giving plasma at a 1:1 ratio with red cells in resuscitation: who might benefit?. Transfusion. 2008;48:1763–1765
  19. Valeri CR, Khuri S, Ragno G. Non-surgical bleeding diathesis in anemic thrombocytopenic patients: role of temperature, RBC, platelets, and plasma clotting proteins. Transfusion. 2007;47:206S–248S
  20. Heaton A, Keegan T, Holme S. In vivo regeneration of red cell 2,3-diphosphoglycerate following transfusion of DPG-depleted AS-1, AS-3 and CPDA-1 red cells. Br J Haematol. 1989;71:131–136
  21. Valeri CR, Hirsch NM. Restoration in vivo of erythrocyte adenosine triphosphate, 2,3-diphosphoglycerate, potassium ion, and sodium ion concentrations following the transfusion of acid–citrate–dextrose-stored human red blood cells. J Lab Clin Med. 1969;73:722–733
  22. Beutler E, Wood L. The in vivo regulation of red cells 2,3 diphosphoglyceric acid (DPG) after transfusion of stored blood. J Lab Clin Med. 1969;74:300–304
  23. Valeri CR. Oxygen transport function of preserved red cells. In Garby L, editor. Clinics in haematology, anaemia and hypoxia, vol. 3, no. 3. Philadelphia, London: Saunders; 1974. p. 649–88.
  24. Valeri CR. Clinical importance of the oxygen transport function of preserved red blood cells. In:  Nicolau C editors. Proceedings of the 12th Katzir-Katchalsky meeting on oxygen transport in red blood cells, 4–7 April 1984, Tours, France. Oxford, England: Pergamon Press; 1986;
  25. Weiskopf RB, Feiner J, Toy P. Red cell age and function. Transfusion. 2008;48:2026
  26. Valeri CR, Rorth M, Zaroulis CG, Jakubowski MS, Vescera S. Physiologic effects of hyperventilation and phlebotomy in baboons: systemic and cerebral oxygen extraction. Ann Surg. 1975;181:99–105
  27. Valeri CR, Rorth M, Zaroulis CG, Jakubowski MS, Vescera S. Physiologic effects of transfusing red blood cells with high or low affinity for oxygen to passively hyperventilated, anemic baboons: systemic and cerebral oxygen extraction. Ann Surg. 1975;181:106–113
  28. Valeri CR, MacGregor H, Giorgio A, Ragno G. Circulation and hemostatic function of autologous fresh, liquid preserved, and cryopreserved baboon platelets transfused to correct an aspirin-induced thrombocytopathy. Transfusion. 2002;42:1206–1216
  29. Khuri SF, Healey N, MacGregor H, Barnard MR, Szymanski IO, Birjiniuk V, et al. Comparison of the effects of transfusions of cryopreserved and liquid-preserved platelets on hemostasis and blood loss after cardiopulmonary bypass. J Thorac Cardiovasc Surg. 1999;117:172–184
  30. Handin RI, Valeri CR. Hemostatic effectiveness of platelets stored at 22°C. N Eng J Med. 1971;285:538–543
  31. Valeri CR. Hemostatic effectiveness of liquid-preserved and previously frozen human platelets. N Eng J Med. 1974;290:353–358
  32. Valeri CR, Feingold H, Marchionni LD. A simple method for freezing human platelets using 6% dimethylsulfoxide and storage at −80°C. Blood. 1974;43:131–136
  33. Melaragno AJ, Carciero R, Feingold H, Talarico L, Weintraub L, Valeri CR. Cryopreservation of human platelets using 6% dimethylsulfoxide and storage at −80°C. Effects of 2 years of frozen storage at −80°C and transportation in dry ice. Vox Sang. 1985;49:245–258
  34. Valeri CR, Ragno G, Khuri S. Freezing human platelets using 6% DMSO with removal of the supernatant solution prior to freezing and storage at −80°C without post-thaw processing. Transfusion. 2005;45(12):1890–1898
  35. Hornsey VS, McMillan L, Morrson A, Drummon O, MacGregor IR, Prowse CV. Freezing of buffy coat-derived, leukoreduced platelet concentrates in 6 percent dimethyl sulfoxide. Transfusion. 2008;48:2508–2514
  36. Moss GS, Valeri CR, Brodine CE. Clinical experience with the use of frozen blood in combat casualties. N Eng J Med. 1968;278:748–752
  37. Valeri CR, Valeri DA, Anastasi J, Vecchione JJ, Dennis RC, Emerson CP. Freezing in the primary polyvinylchloride plastic collection bag: a new system for preparing and freezing nonrejuvenated and rejuvenated red blood cells. Transfusion. 1981;21:138–149
  38. Leal-Noval SR, Jara-Lopez I, Garcia-Carmendia JL, et al. Influence of erythrocyte concentrate storage time on postsurgical morbidity in cardiac surgery patients. Anesthesiology. 2003;98:512–522
  39. Kuduvalli M, Oo AY, Newall N, et al. Effect of perioperative red blood cell transfusion on 30-day and 1-year mortality following coronary artery bypass surgery. Eur J Cardiothorac Surg. 2005;27:592–598
  40. Tinmouth A, Ferguson D, Ye IC, Hebert PC. Clinical consequence of red cell storage in the critically ill. Transfusion. 2006;46:2014–2027
  41. International Forum . Measures to prevent TRALI. Vox Sang. 2007;92:258–277
  42. Valeri CR, Ragno G. Prevention of TRALI. Vox Sang. 2008;94:81
  43. Valeri CR, Ragno G. The effects of preserved red blood cells on the severe adverse events observed in patients infused with hemoglobin based oxygen carriers. Artif Cells Blood Substit Biotechnol. 2008;36(1):3–18
  44. Bennett-Guerrero B, Veldman TH, Doctor A, Telen MJ, Ortel TL, Reid TS, et al. Evolution of adverse changes in stored RBCs. Proc Natl Acad Sci. 2007;104:17063–17068
  45. Valeri CR, Ragno G. Role of nitric oxide in the prevention of severe adverse events associated with blood products. Trans Apher Sci. 2008;39:241–245
  46. Valeri CR. Blood banking and the use of frozen blood products. Boca Raton, FL: Chemical Rubber Company; 1976;
  47. Natanson C, Kern SH, Lurie P, et al. Cell-free hemoglobin-based blood substitute and risk of myocardial infarction and death: a metaanalysis. JAMA. 2008;299:2304–2312
  48. Valeri CR. Viability and function of preserved red cells. N Eng J Med. 1971;284:81–88
  49. Vogel WM, Dennis RC, Cassidy GP, Apstein CS, Valeri CR. Coronary constrictor effect of stroma-free hemoglobin solutions. Am J Physiol. 1986;251(Heart Circ Physiol 20):H413–H420
  50. Valeri CR, Ragno G, Veech RL. Effects of the resuscitation fluid and the HBOC excipient on the toxicity of the HBOC: Ringer’s d,l-lactate, Ringer’s l-lactate, and Ringer’s ketone solutions. Artif Cells Blood Substit Biotechnol. 2006;34(6):601–606
  51. Valeri CR, Ragno G, Veech RL. Severe adverse events associated with hemoglobin based oxygen carriers: role of resuscitative fluids and liquid preserved RBC. Trans Apher Sci. 2008;39:205–211
  52. Hess JR. Review of blood substitutes. Transfus Med Rev. 2006;20:247–248
  53. Chang TMS. Editorial: safety of red blood cell substitutes as compared to stored donor red blood cells. Artif Cells Blood Substit Biotechnol. 2008;36:1–2
  54. Estep T, Bucci E, Farmer M, Greenburg G, Harrington J, Kim HW, et al. Basic science focus on blood substitutes: a summary of the NHLBI Division of Blood Diseases and Resources Working Group Workshop, March 1, 2006. Transfusion. 2008;48:776–782
  55. McCord JH. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med. 1985;312:159–163
  56. Faller MS, Hoidal JR, Ferris PT. Oxygen free radicals in ischemic acute renal failure in the rat. J Clin Invest. 1984;74:1156–1164
  57. Lieberthal W, Fuhro R, Andry C, Valeri CR. Effects of hemoglobin-based oxygen-carrying solutions in anesthetized rats with acute ischemic renal failure. J Lab Clin Med. 2000;135:73–81
  58. Fan H, Sun B, Gu Q, et al. Oxygen radicals trigger activation of NF-kB and AP-1 and upregulation of ICAM-1 in reperfused canine heart. Am J Physiol Heart Circ Physiol. 2002;282:H1778–H1786
  59. Thirunavukkarasu C, Watkins W, Harvey SAK, Gandhi C. Superoxide-induced apoptosis of activated rat hepatic stellate cells. J Hepatol. 2004;41:567–579
  60. Higuchi M, Manna SK, Sasaki R, Aggarwal BB. Regulation of the activation of nuclear factor kappa B by mitochondrial respiratory function: evidence for the reactive oxygen species-dependent and independent pathways. Antioxid Redox Signal. 2002;4:945–950
  61. Fransen E, Maessen JG, Dentener M, Senden N, Buurman W. Impact of blood transfusions on inflammatory mediator release in patients undergoing cardiac surgery. Chest. 1999;116:1233–1239
  62. Dunne JR, Malone DL, Tracy JK, Napolitano LM. Allogeneic blood transfusion in the first 24 hours after trauma is associated with systemic inflammatory response syndrome (SIRS) and death. Surg Infect. 2004;5:395–404
  63. Malone DL, Dunne J, Tracy JK, Putnam AT, Scalea TM, Napolitano LM. Blood transfusion, independent of shock severity, is associated with worse outcome in trauma. J Trauma. 2003;54:898–905
  64. Valeri CR, Zaroulis CG. Rejuvenation and freezing of outdated stored human red cells. N Eng J Med. 1972;287:1307–1313
  65. Valeri CR. Use of rejuvenation solutions in red blood cell preservation. CRC Crit Rev Clin Lab Sci. 1982;17:299–374
  66. Valeri CR, Sims KL, Bates JF, Reichman D, Lindberg JR, Wilson AC. An integrated liquid-frozen blood banking system. Vox Sang. 1983;45:25–39
  67. Valeri CR, Pivacek LE, Gray AD, Cassidy GP, Leavy ME, Dennis RC, et al. The safety and therapeutic effectiveness of human red cells stored at −80°C for as long as 21 years. Transfusion. 1989;29:429–437
  68. Valeri CR, Pivacek LE, Cassidy GP, Ragno G. The survival, function, and hemolysis of human RBCs stored at 4°C in additive solution (AS-1, AS-3, or AS-5) for 42 days and then biochemically modified, frozen, thawed, washed, and stored at 4°C in sodium chloride and glucose solution for 24 hours. Transfusion. 2000;40:1341–1345
  69. Valeri CR, Ragno G, Popovsky MA. Red cell freezing and its impact on the supply chain. [Letter to the Editor] Transfus Med. 2004;14:1–2
  70. Ragno G, Valeri CR. Salvaging of liquid-preserved O-positive and O-negative red blood cells by rejuvenation and freezing. Trans Apher Sci. 2006;35:137–143
  71. Valeri CR, Ragno G, Pivacek LE, Srey R, Hess JR, Lippert LE, et al. A multicenter study of in vitro and in vivo values in human RBCs frozen with 40-percent (wt/vol) glycerol and stored after deglycerolization for 15 days at 4°C in AS-3: assessment of RBC processing in the ACP 215. Transfusion. 2001;41:933–939
  72. Valeri CR, Ragno G, Pivacek LE, O’Neill EM. In vivo survival of apheresis RBCs, frozen with 40-percent (wt/vol) glycerol, deglycerolized in the ACP 215, and stored at 4°C in AS-3 for up to 21 days. Transfusion. 2001;41:928–932
  73. Valeri CR, Ragno G. Automation of the glycerolization of the RBC using the high separation bowl in the Haemonetics ACP215 instrument. Transfusion. 2005;45(10):1621–1627
  74. Bandarenko N, Hay SN, Holmberg J, Whiteley P, Taylor HL, Moroff G, et al. Extended storage of AS-1 and AS-3 leukoreduced red blood cells for 15 days after deglycerolization and resuspended in AS-3 using an automated closed system. Transfusion. 2004;44:1656–1662
  75. Bandarenko N, Cancelas JA, Snyder E, Hay SN, Rugg N, Corda T, et al. Successful in vivo recovery and extended storage of AS-5 red blood cells following deglycerolization and resuspension in AS-3 for 15 days using an automated closed system. Transfusion. 2007;47:680–686
  76. Grose HL, Byrne KM, Sanata JM, Rentas PL, Stroncel DE. In vitro variables of red blood cell components collected by apheresis and frozen 6 and 14 days after collection. Transfusion. 2006;46:1178–1183
  77. Valeri CR, Altschule MD. Hypovolemic anemia of trauma: the missing blood syndrome. Boca Raton, FL: Chemical Rubber Company; 1981;
  78. Noorman F, Streliski R, Lelkens CC. Frozen −80°C red cells, plasma and platelets in combat casualty care. Transfusion. 2009;49(3S):26A [Supplement]
  79. Szymanski IO, Valeri CR. Clinical evaluation of concentrated red cells. N Eng J Med. 1969;280:281–287
  80. Valeri CR, Szymanski IO, Zaroulis CG. 24-Hour survival of ACD- and CPD-stored red cells. I. Evaluation of nonwashed and washed stored red cells. Vox Sang. 1972;2:289–308
  81. Valeri CR, Gray AD, Cassidy GP, Riordan W, Pivacek LE. The 24-hour posttransfusion survival, oxygen transport function, and residual hemolysis of human outdated-rejuvenated red cell concentrates after washing and storage at 4°C for 24 to 72 hours. Transfusion. 1984;24:323–326
  82. Grahmer C, Holmberg J, Popovsky M, Amann E, Schonitzer D, Falaize S, et al. Up to 21-day banked red blood cells collected by apheresis and stored for 14 days after automated washed at different times of storage. Vox Sang. 2006;90:40–44

PII: S1473-0502(10)00064-9

doi: 10.1016/j.transci.2009.08.001

Transfusion and Apheresis Science
Volume 42, Issue 3 , Pages 223-233 , June 2010

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