Research Article| Volume 9, ISSUE 3, P275-281, 1988

Changes in red cell and platelet antigen strength during storage

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      The limited available data indicate that platelet antigens A, B, 2H, Plal, and HLA-I show no change in reactivity during a 10-day period of storage as routine platelet concentrates. At the molecular level, the lack of change in Plal is consistent with the minimal changes in platelet glycoprotein III during storage. The reported deterioration of GPI suggests that Plel might be altered during storage, while the stability of GPII would suggest that Leka (Baka) may show stability paralleling Plal. Known changes in red cell antigens during routine storage include a decrease of Pl and Lewis expression, but variable results have been reported for A, B, D, E, c, K, k, Fya, Fyb, Jka, M, S and U. The causes for altered red cell antigen expression remain poorly understood but may involve shedding of membrane vesicles during aging. The possible roles of senescent and storage-related neoantigens remain speculative.
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