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Abstract
Little is known concerning the biochemical and physiological changes that take place
in lymphocytes and monocytes in various blood components stored under blood bank conditions.
Several studies have suggested that these cells become nonviable after some days of
storage, and that surface markers for various lymphocyte subsets may vary over time
and with different conditions of storage. The best documented consequences of transfusion
of such cells is graft versus host disease in the immunologically immature or dysfunctional
recipient, and prolonged survival of renal allografts in previously transfused recipients.
Recipient immunomodulation in other settings may be mediated by these cells, or their
remnants, which are almost invariably transfused along with red blood cells, platelets
or plasma factors. Some proposed consequences of homologous blood transfusions which
may be related to transfusion of cells of the immune system include decreased host
resistance to solid tumor recurrence, bacterial infection and HIV-1 infection.
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helper/inducer T lyumphocytes prevent spotaneous diabetes in the BB/W rat.Article info
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© 1988 Published by Elsevier Inc.
