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Abstract
Changes in plasma coagulation factors during blood storage primarily consist of a
gradual reduction in biologic activity. The major exception is the more rapid loss
of coagulation factor V and VIII activity due to their lability. By 35 days of storage
of whole blood in CPD-Adenine, factor V falls to 15–21% activity and factor VIII 16–20%.
Only slight declines are seen in factor II and X during the same time, while other
factors, except for factor VII, are virtually unchanged. Factor VII may be activated
in the cold, but otherwise declines slightly. In fresh frozen plasma stored for a
year only factor VIII declines, and this is reduced by more rapid freezing to lower
temperatures. In platelet concentrates, coagulation factors are well maintained, with
the exception of the labile factors. Paradoxically, factor V falls more rapidly with
room temperature storage and agitation while factor VIII decline is lessened.
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© 1988 Published by Elsevier Inc.
