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Abstract
The risks of ABO-mediated acute immune hemolytic transfusion reactions continue to
bedevil modern transfusion services. Of particular concern, the incidence of transfusion
fatalities has not changed over time, in stark comparison to the fall in risks of
infectious diseases. This article reviews the approaches employed to combat aspects
of ABO transfusion errors. The advantages of a universal group O donor pool are considered,
and some innovative approaches for achieving this goal, including enzymatic modification
of the red cell membrane, the epitope masking through the use of polyethylene glycol,
are described. The impact of a group O blood supply on transfusion practices, and
on costs to healthcare system, are considered.
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© 1997 Published by Elsevier Inc.
