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Abstract
Rheological parameters (plasma and blood viscosities, erythrocyte aggregation and
deformability) are very relevant to a better understanding of the changes inflicted
on the properties of blood in various hematological diseases (monoclonal gammopathies
in particular). This study reports the measurement of rheological parameters (plasma
and blood viscosity, RBC aggregation and deformability) in hematological disorders
where abnormal blood properties have been described. All these diseases are treated
by means of blood separators (therapeutic haemapheresis: plasma exchange, plasma processing,
or erythrocyte exchange). We monitored plasma viscosity in 50 patients with monoclonal
gammopathies: before and after each exchange (PE) or plasma processing (PP) sessions.
Hyperviscosity was reduced in all cases after plasma exchange. Erythrocyte aggregation
in gammopathies was also tested (15 multiple myelomas) treated by PE or PP; EA abnormalities
and therapy-induced changes are described. EA is also modified by erythropheresis
(seven sickle cell anemias). Measurement of rheological parameters are useful to the
diagnosis of rheological abnormalities, as well as to assess the impact of therapeutic
hemapheresis techniques like plasma exchange, plasma treatment, erythrocytapheresis.
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Article info
Publication history
Accepted:
July 15,
1997
Received:
January 23,
1997
Identification
Copyright
© 1997 Published by Elsevier Inc.
