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Research Article| Volume 20, ISSUE 1, P83-94, February 1999

Results of an open, longitudinal multicenter LDL-apheresis trial

      LDL-apheresis originated in 1981 as the Apoprotein B specific elimination of cholesterol [

      Stoffel W, Demant T. Selective removal of apolipoprotein B-containing serum lipoproteins from blood plasma. Proc Natl Acad Sci USA 1981;78:611–615

      ,

      Stoffel W, Borberg H, Greve V. Application of specific extracorporeal removal of low density lipoprotein in familial hypercholesterolaemia. Lancet II 1981:1005–1007

      ]. At that time the elimination of LDL-cholesterol was generally nonspecific using plasma exchange [

      De Gennes JL, Toutaine R, Maunand B, Truffert J, Laudat P. Forme homozygotes cutaneo-tendineuses de xanthomatose hypercholesterolèmique dans une observation familiale exemplaire. Essai de plasmaphèrése a titre de traitement heroique. Bull. Mem. Soc. Hop. Paris 1967;118:1377–13402

      ,

      Thompson GR, Myant NB, Kilpatrick D, Oakley CM, Raphael MJ, Steiner RE. Assessment of long-term plasma exchange for familial hypercholesteroaemia. Brit Heart J 1980;43:680–688

      ,

      Thompson GR, Miller P, Breslow JL. Improved survival of patients with homozygous familial hypercholesteroaemia treated by plasma exchange. Brit Med J 1985;291:1671–1673

      ]as the only available procedure, however filtration as a semiselective approach was about to be introduced [

      Kadar JG, Späth PJ, Gaczkowski A, Oette K, Stoffel W, Borberg H. Biocompatibility studies on a clinically well tolerated extracorporeal system. Plasma Ther Transfus Technol 1988;8:307–318

      ,

      Koga N, Sato T, Kurashige Y, Nagano T, Hashizume K, Iwamoto H. Longterm effects of LDL-liposorption on coronary and carotid athersosclerosis in familial hypercholesterolaemia opatients. In: Yamamoto A, editor. Therapeutic plasmapheresis XVI. Jpn J Apheresis 1997, p. 63–68

      ]. The name LDL-apheresis was also introduced in 1981 for this, until now, unique procedure based on the principle of immunoadsorption (therapeutic affinity chromatography). Although it was later also used for other technologies, we still restrict the nomenclature to the original procedure.
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