The ABO blood group has been associated with risk of thrombosis. There is strong evidence
on the positive association between non-O blood group and higher risk of thrombotic
events [
[1]
]. However, it is not known whether blood group O individuals are at higher risk of
bleeding, as has been suggested by some papers recently published [
2
,
3
,
4
]. A possible explanation for these findings is that individuals of blood group O have
lower levels of von Willebrand factor (VWF) and factor VIII, and increased bleeding
time [
[5]
]. End-stage chronic liver disease (CLD) affects both primary and secondary hemostasis
because it is associated with thrombocytopenia and reduced levels of procoagulation
factors (and anticoagulation factors as well). These alterations confer to the patient
a fragile equilibrium of hemostasis [
[6]
]. Orthotopic liver transplantation (OLT) is a challenge to hemostasis, as patients
with CLD present alterations of both primary and secondary hemostasis through a number
of mechanisms [
[7]
]. There were identified some factors associated with increased blood components requirements
after OLT [
[8]
]. The aim of this study was to evaluate the impact of ABO blood group on bleeding
in patients with CLD submitted to OLT. Our hypothesis was that patients with type
O blood group present a higher risk of bleeding.To read this article in full you will need to make a payment
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References
- ABO blood group as a potential risk factor for venous thromboembolism in acutely injured patients.Thromb Haemost. 2011; 105: 5-13
- The relationship between ABO blood group and the risk of bleeding during vitamin K antagonist treatment.J Thromb Haemost. 2006; 4: 1418-1420
- Is there an association between blood group O and epistaxis?.J Laryngol Otol. 2008; 122: 366-368
- Clarifying the relationship between ABO/Rhesus blood group antigens and upper gastrointestinal bleeding.Dig Dis Sci. 2009; 54: 1029-1034
- Bleeding time, blood groups and von Willebrand factor.Br J Haematol. 1989; 73: 217-220
- Haemostasis and thrombosis in liver disease.Br J Haematol. 2010; 148: 507-521
- New insights into the coagulopathy of liver disease and liver transplantation.World J Gastroenterol. 2006; 12: 7725-7736
- Preoperative variables associated with transfusion requirements in orthotopic liver transplantation.Transfusion Apher Sci. 2013; ([Epub ahead of print])
- Orthotopic liver transplantation with preservation of the inferior vena cava.Ann Surg. 1989; 210: 649-652
- Possible effect of secretor locus on plasma concentration of factor VIII and von Willebrand factor.Blood. 1989; 73: 990-993
Article info
Publication history
Published online: February 03, 2014
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© 2014 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
