Abstract
Background
Granulocyte colony stimulating factor (G-CSF) given for 4–6 days is commonly used
for mobilization of allogeneic stem cell donors. The primary objective of this study
is to compare the yield of stem cell mobilization, assessed using a surrogate endpoint
of CD34+ cell count, between Day 4 and Day 6.
Study design and Methods
In this retrospective study we included all allogeneic stem cell donors mobilized
with G-CSF for 6 days from January 2003 until October 2015 in the bone marrow transplantation
unit at a tertiary academic center. Of 106 donor records reviewed, 84 were with available
data and selected for the study.
Results
We included 84 donors with median age and weight of 19 years and 60 kg respectively.
The median Day 4 WBC and CD34+ cell count were 37.4 × 109/L and 54 × 106/L respectively; while the median Day 6 WBC and CD34+ cell count were 44.4 × 109/L and 86 × 106/L respectively with a statistically significant difference from Day 4 (P < 0.001). In the multivariable model, there were no significant impact of donor’s
age (P = 0.215), weight (P = 0.108), height (P = 0.428) and mean corpuscular volume (P = 0.263) on the difference in CD34+ cell yield. However, the donor's blood group AB predicated a significantly higher
difference (P = 0.036).
Conclusion
Six days of G-CSF mobilization achieves higher CD34+ cell count than 4 days in allogeneic stem cell donors especially in donors with blood
group AB, albeit both approaches give count higher than the successful collection
threshold.
Keywords
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Article info
Publication history
Published online: January 09, 2020
Accepted:
December 30,
2019
Received in revised form:
December 8,
2019
Received:
September 7,
2019
Identification
Copyright
© 2020 Elsevier Ltd. All rights reserved.
