Abstract
Background
It remains controversial whether granulocyte transfusions as a supportive treatment
improve survival in patients with febrile neutropenia or granulocyte dysfunctions.
We describe survival rates subsequent to granulocyte transfusions in pediatric and
adults patients treated at a major blood center in Brazil.
Material and methods
We retrospectively reviewed the clinical charts of pediatric and adult patients treated
with granulocyte transfusions at our institution from January 2000 to October 2019.
We assessed demographic characteristics, clinical features, indications for transfusion,
units transfused, dose of granulocytes administered and survival rates 30 and 100
days after the initial transfusion.
Results
We identified 64 pediatric and 67 adult patients treated with 262 granulocyte transfusions.
An optimal dose (> 0.6 × 109 granulocytes per kilogram per transfused unit) was available for transfusion in 80.4
% of pediatric patients but in only 19.6 % of adults (p = 0.017). Thirty days after
their first granulocyte transfusion, 38 (59.4 %) pediatric and 61 (91 %) adult patients
had died. Patients receiving the optimal dose of granulocytes had better survival
outcomes, but even among this sub-group, adults were more likely to die than were
children either at 30 days (OR = 8.67, 95 %CI 2.69–34.9) or 100 days (OR = 6.27, 95
%CI 1.86–25.9) after their initial granulocyte transfusion.
Conclusion
Survival rates following granulocyte transfusion varied by the dose transfused and
were higher in children than in adults.
Keywords
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Article info
Publication history
Published online: October 26, 2021
Accepted:
October 23,
2021
Received in revised form:
October 8,
2021
Received:
August 18,
2021
Identification
Copyright
© 2021 Elsevier Ltd. All rights reserved.
