Abstract
Introduction
Immediate adverse reactions experienced during donation decrease return rates among
whole-blood donors, but little is known about this effect among platelet apheresis
donors. We investigated the impact of immediate adverse reactions on the return rates
of volunteer apheresis platelet donors.
Methods
In a sample of 4108 consecutive platelet apheresis donors seen from August 2016 through
June 2019, we evaluated whether immediate adverse reactions were associated with returning
for a subsequent platelet apheresis donation within a 12-month period. We used propensity
score matching to compare donors with and without adverse reactions.
Results
An immediate adverse reaction occurred in 312 (7.6%) donors; 98.5% were mild, and
0.3% were severe. Of the original 4108 platelet apheresis donors, only 3211 (72.3%)
returned for a subsequent donation within 12 months. Experiencing an immediate adverse
reaction during the donation process significantly decreased the return rate for a
subsequent donation [HR= 0.74 (0.63–0.87)], especially among female donors [HR= 0.70
(0.53–0.93)], donors aged < 30 years [HR= 0.71 (0.54–0.94)], with a high school educational
level [0.63 (0.49–0.81)], donors donating for the first time [HR= 0.73 (0.59–0.90)],
and repeat donors with a previous platelet apheresis donation more than 180 days prior
[HR= 0.68 (0.50–0.93)].
Conclusion
Even mild adverse events reduce the return rates for a subsequent donation among platelet
apheresis donors. Female donors, younger donors, and first-time donors are at higher
risk of not returning after an immediate adverse reaction. Preventing the incidence
of immediate adverse reactions during platelet apheresis donation may increase the
rate of donor retention.
Keywords
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References
- Adverse reactions and other factors that impact subsequent blood donation visits.Transfusion. 2012; 52: 118-126
- Do reactions after whole blood donation predict syncope on return donation?.Transfusion. 2012; 52: 2570-2576
- Donor anxiety, needle pain, and syncopal reactions combine to determine retention: a path analysis of two-year donor return data.Transfusion. 2013; 53: 1992-2000
- Recovery of platelet count among apheresis platelet donors.J Clin Diagn Res JCDR. 2016; 10 (Ec01-ec4)
- Complications of donor apheresis.J Clin Apher. 2006; 21: 132-141
- Clinical indications and adverse reactions of platelet apheresis.J Coll Physicians Surg Pak JCPSP. 2015; 25: 403-406
- A retrospective analysis of apheresis donor deferral and adverse reactions at a tertiary care centre in India.J Clin Diagn Res JCDR. 2016; 10 (Ec22-ec4)
- Risk factors associated with the occurrence of adverse events in plateletpheresis donation.Rev Bras Hematol Hemoter. 2014; 36: 191-195
- Adverse reactions in blood and apheresis donors: experience from two Italian transfusion centres.Blood Transfus. 2009; 7: 35-38
- Donor safety in haemapheresis: development of an internet-based registry for comprehensive assessment of adverse events from healthy donors.Transfus Med Hemother Off Organ Dtsch Ges Transfus Immunhamatol. 2017; 44: 188-200
- Frequency of adverse events in plateletpheresis donors in regional transfusion centre in North India.Transfus Apher Sci Off J World Apher Assoc Off J Eur Soc Haemapher. 2013; 49: 244-248
National Hemovigilance Guidelines Brazil 2015. Brazilian Health Regulatory Agency, Brazil; 2015.
ISBT. Standard for surveillance of complications related to blood donation; 2014.
- Propensity score method: a non-parametric technique to reduce model dependence.Ann Transl Med. 2017; 5: 7
- Adverse events and safety issues in blood donation--a comprehensive review.Blood Rev. 2012; 26: 33-42
- Arm complications after manual whole blood donation and their impact.Transfus Med Rev. 2013; 27: 44-49
- Donor vigilance: what are we doing about it?.Biol J Int Assoc Biol Stand. 2012; 40: 176-179
- Interventions to reduce vasovagal reactions in blood donors: a systematic review and meta-analysis.Transfus Med. 2016; 26: 15-33
- The impact of delayed and immediate adverse events on the intention of future donations in whole blood and plateletpheresis donors.J Clin Apher. 2021; 36: 621-627
- Adverse events in platelet apheresis donors: a multivariate analysis in a hospital-based program.Vox Sang. 1999; 77: 24-32
- Frequency of immediate adverse effects associated with apheresis donation.Transfusion. 1998; 38: 938-943
- The American Red Cross donor hemovigilance program: complications of blood donation reported in 2006.Transfusion. 2008; 48: 1809-1819
- The safety profile of automated collections: an analysis of more than 1 million collections.Transfusion. 2007; 47: 1002-1005
- Retention of “safe” blood donors. The retrovirus epidemiology donor study.Transfusion. 1998; 38: 359-367
- Donors who react may not come back: analysis of repeat donation as a function of phlebotomist ratings of vasovagal reactions.Transfus Apher Sci Off J World Apher Assoc Off J Eur Soc Haemapher. 2005; 33: 99-106
- Adverse reactions to blood donations: the READ project.Blood Transfus. 2010; 8: 49-62
- What motivates men to donate blood? A systematic review of the evidence.Vox Sang. 2018; 113: 205-219
- Interdonation intervals and patterns of return among blood donors in Brazil.Transfusion. 2012; 52: 722-728
- Why do young men lapse from blood donation?.Vox Sang. 2019; 114: 566-575
- National audit of citrate toxicity in plateletpheresis donors.Transfus Med. 2002; 12: 187-191
- Easy come, easy go. Retention of blood donors.Transfus Med. 2015; 25: 227-233
- Water administration and the risk of syncope and presyncope during blood donation: a randomized clinical trial.Transfusion. 2012; 52: 2577-2584
- Psychometric properties of the blood donation reactions inventory: a subjective measure of presyncopal reactions to blood donation.Transfusion. 2008; 48: 1820-1826
- Vasovagal reactions in blood donors: risks, prevention and management.Transfus Med. 2019; 29: S13-S22
Article info
Publication history
Published online: March 15, 2022
Accepted:
March 13,
2022
Received in revised form:
February 22,
2022
Received:
November 30,
2021
Identification
Copyright
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