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The impact of immediate adverse donation reactions on the return of volunteers undergoing platelet apheresis

  • Cássio Lins Gil de Farias
    Affiliations
    Departamento de Hematologia, Hemoterapia e Terapia Celular da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil
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  • Lucas Bassolli
    Affiliations
    Departamento de Hematologia, Hemoterapia e Terapia Celular da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil

    Laboratório de Investigação Médica na Patogênese e Terapia dirigida em Onco-imuno-hematologia (LIM-31), Hospital das Clinicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil
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  • Alfredo Mendrone-Junior
    Affiliations
    Laboratório de Investigação Médica na Patogênese e Terapia dirigida em Onco-imuno-hematologia (LIM-31), Hospital das Clinicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil

    Fundação Pró-Sangue – Hemocentro de São Paulo, São Paulo, SP, Brazil
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  • Cyntia de Araújo Arrais
    Affiliations
    Laboratório de Investigação Médica na Patogênese e Terapia dirigida em Onco-imuno-hematologia (LIM-31), Hospital das Clinicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil
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  • Amanda Duran
    Affiliations
    Departamento de Hematologia, Hemoterapia e Terapia Celular da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil
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  • Vanderson Rocha
    Affiliations
    Departamento de Hematologia, Hemoterapia e Terapia Celular da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil

    Laboratório de Investigação Médica na Patogênese e Terapia dirigida em Onco-imuno-hematologia (LIM-31), Hospital das Clinicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil

    Fundação Pró-Sangue – Hemocentro de São Paulo, São Paulo, SP, Brazil

    Haematology Department, Churchill Hospital, NHS-BT, Oxford University, Oxford, UK
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  • Cesar de Almeida-Neto
    Correspondence
    Correspondence to: Avenida Dr. Enéas Carvalho de Aguiar, 155-1º andar, Consolação, São Paulo, SP, Brazil.
    Affiliations
    Fundação Pró-Sangue – Hemocentro de São Paulo, São Paulo, SP, Brazil

    Disciplina de Ciências Médicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil
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      Abstract

      Introduction

      Immediate adverse reactions experienced during donation decrease return rates among whole-blood donors, but little is known about this effect among platelet apheresis donors. We investigated the impact of immediate adverse reactions on the return rates of volunteer apheresis platelet donors.

      Methods

      In a sample of 4108 consecutive platelet apheresis donors seen from August 2016 through June 2019, we evaluated whether immediate adverse reactions were associated with returning for a subsequent platelet apheresis donation within a 12-month period. We used propensity score matching to compare donors with and without adverse reactions.

      Results

      An immediate adverse reaction occurred in 312 (7.6%) donors; 98.5% were mild, and 0.3% were severe. Of the original 4108 platelet apheresis donors, only 3211 (72.3%) returned for a subsequent donation within 12 months. Experiencing an immediate adverse reaction during the donation process significantly decreased the return rate for a subsequent donation [HR= 0.74 (0.63–0.87)], especially among female donors [HR= 0.70 (0.53–0.93)], donors aged < 30 years [HR= 0.71 (0.54–0.94)], with a high school educational level [0.63 (0.49–0.81)], donors donating for the first time [HR= 0.73 (0.59–0.90)], and repeat donors with a previous platelet apheresis donation more than 180 days prior [HR= 0.68 (0.50–0.93)].

      Conclusion

      Even mild adverse events reduce the return rates for a subsequent donation among platelet apheresis donors. Female donors, younger donors, and first-time donors are at higher risk of not returning after an immediate adverse reaction. Preventing the incidence of immediate adverse reactions during platelet apheresis donation may increase the rate of donor retention.

      Keywords

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