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ABO group-based strategy for inventory management of methylene blue-treated thawed plasma in a blood bank

      The immediate availability of blood products for patients with massive bleeding is critical since the delay in transfusion has been related to an increase in mortality [
      • Meyer D.E.
      • Vincent L.E.
      • Fox E.E.
      • OʼKeeffe T.
      • Inaba K.
      • Bulger E.
      • et al.
      Every minute counts: time to delivery of initial massive transfusion cooler and its impact on mortality.
      ]. This pressure is transferred to blood banks, where the storage temperature for red blood cell (RBC) concentrates and platelets allows a fast delivery of these components [
      • European Commission
      ]. However, plasma is usually stored at ≤ −25 ºC and requires to be thawed in a water bath at 37 ºC for 30 min [
      • European Commission
      ]. In order to avoid this delay, most blood banks keep a stock of liquid-state plasma units permanently available for massive transfusion (MT) [
      • Beattie G.
      • Cohan C.M.
      • Ng V.L.
      • Victorino G.P.
      Liquid plasma: a solution to optimizing early and balanced plasma resuscitation in massive transfusion.
      ].

      Abbreviations:

      RBC (Red Blood Cells), MT (Massive Transfusion), MB-FFP (Methylene blue-treated fresh frozen plasma), F. VIII (Factor VIII), FFP (Fresh Frozen Plasma), TP (Thawed Plasma), EDQM (European Directorate for Quality of Medicines and Healthcare), CI (Confidence Interval)
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