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Detection of anti-B antibodies in a patient with A1B blood group: A case report and literature review

  • Author Footnotes
    1 0000-0003-3528-7729
    Hee-Jeong Youk
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    1 0000-0003-3528-7729
    Affiliations
    Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
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  • Author Footnotes
    2 0000-0003-0166-2084
    Jin Seok Kim
    Footnotes
    2 0000-0003-0166-2084
    Affiliations
    Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
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  • Author Footnotes
    3 0000-0002-0574-9200
    Hyungsuk Kim
    Footnotes
    3 0000-0002-0574-9200
    Affiliations
    Department of Laboratory Medicine, Seoul National University Hospital, Seoul, South Korea
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  • Author Footnotes
    4 0000-0003-3201-5728
    Sang-Hyun Hwang
    Footnotes
    4 0000-0003-3201-5728
    Affiliations
    Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
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  • Author Footnotes
    5 0000-0001-6728-4640
    Heung-Bum Oh
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    5 0000-0001-6728-4640
    Affiliations
    Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
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  • Author Footnotes
    6 0000–0002-5197–6340
    Yousun Chung
    Correspondence
    Correspondence to: Department of Laboratory Medicine, Kangdong Sacred Heart Hospital, 150, Sungan-ro, Kangdong-gu, Seoul 05355, South Korea.
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    6 0000–0002-5197–6340
    Affiliations
    Department of Laboratory Medicine, Kangdong Sacred Heart Hospital, Seoul, South Korea
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  • Author Footnotes
    7 0000–0002-9781–0928
    Dae-Hyun Ko
    Correspondence
    Correspondence to: Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea.
    Footnotes
    7 0000–0002-9781–0928
    Affiliations
    Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
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  • Author Footnotes
    1 0000-0003-3528-7729
    2 0000-0003-0166-2084
    3 0000-0002-0574-9200
    4 0000-0003-3201-5728
    5 0000-0001-6728-4640
    6 0000–0002-5197–6340
    7 0000–0002-9781–0928

      Abstract

      ABO antibodies occur naturally and usually exist as alloantibodies. They are the most clinically significant in cases of transfusions. However, there are very few reports on auto-anti-A or B. A 58-year-old man visited our hospital for evaluation of an inguinal mass. Blood typing was performed, while preparing the patient for an excisional biopsy. Forward and reverse typing showed a typical AB and A pattern. Results of the direct antiglobulin and unexpected antibody screening tests were negative. The serum did not react with AB3 cells. The biopsy revealed a diffuse large B-cell lymphoma. After completing four cycles of R-CHOP chemotherapy, the patient achieved complete remission. There were no anti-B antibodies found on repeat ABO typing. This report shares our experience on unexpected anti-B antibody findings in a patient with an A1B blood type. To the best of our knowledge, this is the first report of anti-B antibodies in a patient with an A1B blood type in Korea.

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