Abstract
Introduction
Exchange transfusion (ECT) is one of effective treatments for rapid reduction of the
bilirubin serum levels. The main purpose of this study was to offer greater insights
into the effects of ECT on the hematologic factors and bilirubin in neonatal hyperbilirubinemia.
Methods
This cross-sectional study was performed on 380 neonates over 35 gestational weeks,
and 2–14 days old with a bilirubin of above 17 mg/dl who had undergone ECT at Ghaem
Hospital of Mashhad in Iran from 2011 to 2021. Blood samples were examined before,
immediately after, 6 h and 60 h after ECT for complete blood cell count (CBC), platelet
count and bilirubin serum level analysis.
Results
In this study, the mean age of neonates was 5.21 ± 3.55 days with a mean birth weight
of 2810 ± 710 gr. The mean platelet count (PLT), white blood cell (WBC) and the serum
level of bilirubin were estimated at 260,000/mm2, 12,400/mm2, 23 mg/dl before ECT and 97,000/mm2, 7370//mm2 and 12.6 mg/dl immediately after ECT, respectively (P-value <0.001).
Conclusion
The results indicated that the mean serum levels of bilirubin, platelets, and leukocytes
dropped to 55%, 30%, and 60% of their baseline levels before ECT, respectively, but
they all spiked after ECT.
Abbreviations:
RBC (Red Blood Cell), ECT (Exchange Transfusions), WBCs (White Blood Cells), pRBC (packed Red Blood Cells), FFP (Fresh Frozen Plasma)Keywords
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Article info
Publication history
Published online: April 25, 2022
Accepted:
April 22,
2022
Received in revised form:
April 21,
2022
Received:
February 11,
2022
Identification
Copyright
© 2022 Elsevier Ltd. All rights reserved.
