Platelets have been studied and used for more than forty years in the treatment of
ulcerative, chronic wounds [
[1]
], alongside alternatives among which dressings of various types and physicochemical
designs, skin substitutes, negative pressure or hyperbaric oxygen techniques, and
growth factors [
[2]
]. Measures promoting anti-infection, anti-oxidation, immunoregulation, angiogenesis,
and tissue remodeling have been sought of, among the many prospective venues [
[3]
]. All these properties are exerted by several agents such as bee venom and therapeutic
honey, and – of particular notice – by platelets [
[4]
]. The potential use blood platelets thus, makes sense in the arsenal of measures to
treat ulcerative wounds. Indeed, blood platelets have multiple roles apart from their
seminal initiation of clotting and coagulation; their sense dangers, of which vascular
endothelium attrition, they make the needed repairs to prevent blood leaking into
tissues, they initiate inflammation and innate immunity that take place to the defense
against infectious invaders, and they repair damaged tissues as they switch from a
proinflammatory profile of secretion to an anti-inflammatory one [
5
,
6
,
7
]. The healing process is a long way, that in general terminates the inflammatory-anti-inflammatory
process [
[8]
]. Platelets take an important role in this instrumental part of the innate immunity
response to tissue damage, thanks to the numerous factors that are secreted by platelets
through their activation steps [
9
,
10
,
11
]; platelets further exert anti-apoptotic roles and interact with regenerative cells
[
[12]
].Keywords
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Published online: May 20, 2022
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