Abstract
Background
Although indications of fresh frozen plasma (FFP) usage are limited to certain circumstances
in children, there is an increasing trend towards inappropriate usage are reported
in clinical practice. The aim of this study was to evaluate the appropriateness of
pediatric FFP utilization in our tertiary care hospital.
Methods
This prospective observational study was conducted at a tertiary care academic pediatric
hospital. All FFP orders were evaluated for appropriateness over a 4-monts period
by 2 hematologists. Data collected include demographic information, diagnosis, FFP
transfusion indication, pre-transfusion coagulation tests, surgical procedure or bleeding
status, and transfusion reactions.
Results
Three hundred twenty-four patients (57 % males, 43 % females) were transfused in 987
episodes. The mean age of the patients was 5.4±5.7 years. The majority of the patients
(33 %) were under 1 y of age and the products were primarily utilized by pediatric
and cardiovascular intensive care units. Pre-transfusion coagulation testing was only
available in 674 (68 %) of the transfusion episodes. The rate of appropriate FFP transfusion
episodes was 59 % (587/987). Inappropriate usage was mostly related to sepsis and
minor coagulation abnormalities without bleeding. The higher rates of inappropriate
transfusion orders were observed in pediatric and neonatal intensive care units, and
hematology/oncology departments.
Conclusions
Inappropriate use of FFP in children remains a significant challenge. The regular
audit and sustainable education programs targeting the efficient use of FFP for health
professionals at the national level can improve transfusion practices.
Keywords
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Article info
Publication history
Published online: May 25, 2022
Accepted:
May 23,
2022
Received in revised form:
April 28,
2022
Received:
February 16,
2022
Footnotes
☆This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Identification
Copyright
© 2022 Elsevier Ltd. All rights reserved.
