Highlights
- •The largest prospective study to date of timing of hypotensive AEs in plasma donors.
- •None of the analyzed donor characteristics were associated with time to hypotensive AE.
- •However, repeat donors tended to have AEs ~6 min later vs naïve donors (non-significant).
- •No early peak in hypotensive AEs as typically seen in whole blood donation
- •This was unexpected given a similar hypovolemic challenge early during plasmapheresis.
Abstract
Background and objectives
Materials and methods
Results
Conclusion
Keywords
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Transfusion and Apheresis ScienceReferences
Plasma Protein Therapeutics Association. Total Collections in the U.S. Cited 2022 May 19. Available from 〈https://www.pptaglobal.org/images/Data/Plasma_Collection/Total_Yearly_Collections_2008–2019.pdf〉.
- Personalized collection of plasma from healthy donors: a randomized controlled trial of a novel technology-enabled nomogram.Transfusion. 2021; 61: 1789-1798
- Source plasma collection in the United States: toward a more personalized approach.Am J Hematol. 2020; 95
- Plasma is a strategic resource.Transfusion. 2016; 56: 3133-3137
- Supply and demand for plasma-derived medicinal products - a critical reassessment amid the COVID-19 pandemic.Transfusion. 2020; 60: 2748-2752
- Google trends as an early indicator for shortages of intravenous immunoglobulin (IVIG).Transfusion. 2020; 60: 1656-1657
- A single-centre study of vasovagal reaction in blood donors: Influence of age, sex, donation status, weight, total blood volume and volume of blood collected.Asian J Transfus Sci. 2014; 8: 43-46
American Red Cross. U.S. Blood Supply Facts. Importance of the Blood Supply. Cited 2022 May 19. Available from 〈https://www.redcrossblood.org/donate-blood/how-to-donate/how-blood-donations-help/blood-needs-blood-supply.html〉.
- Repeat donation and deferral rates in US source plasma donors: Exploratory analysis from the IMPACT trial.Transfusion. 2021; 61: 2849-2854
- Delayed adverse reactions to blood donation.Transfusion. 2010; 50: 556-565
Plasma Protein Therapeutics Association. IQPP Donor Fluid Administration Standard. Plasma Protein Therapeutics Association. Cited 2022 May 19. Available from 〈www.pptaglobal.org〉.
Plasma Protein Therapeutics Association. IQPP Standard for Recording Donor Adverse Events. Plasma Protein Therapeutics Association. Cited 2022 May 19. Available from 〈https://www.pptaglobal.org/images/IQPP/Standards_Revisions/2018/IQPP_DAERS_V2.pdf〉.
- Nonparametric Statistical Methods. third ed. Wiley, New York2015
Gustafson M. Source Plasma Donor Hemovigilance Activities and Results. Cited 2022 May 19. Available from 〈https://www.pptaglobal.org/images/presentations/2017/Gustafson_PlasmaVigilance100817.pdf〉.
- Plasmavigilance-adverse events among US Source plasma donors.Transfusion. 2021; 61: 2941-2957
ClinTrials.gov. Prospective, randomized, controlled, multicenter clinical trial to demonstrate the safety and effectiveness of the NexSys® PCS Plasma Collection System with the Percent Plasma Nomogram (PPN) Feature. Investigational Plan. Cited 2022 May 19. Available from 〈https://clinicaltrials.gov/ProvidedDocs/23/NCT04320823/Prot_001.pdf〉.
- Management of young blood donors.Transfus Med Hemother. 2014; 41: 284-295
- Factors associated with vasovagal reactions in apheresis plasma and whole blood donors: a statistical-epidemiological study in a European donor cohort.Blood Res. 2016; 51: 293-296
