Abstract
Background
With the use of granulocyte colony stimulating factor (G-CSF) after allogeneic hematopoietic
stem cell transplantation (HSCT), the duration of neutrophil engraftment and hospitalization
were shortened. However, there is no consensus on the effect of G-CSF on platelet
engraftment time. The primary aim of our study is to determine the effect of G-CSF
use on platelet engraftment time after HSCT. Secondary purposes are to determine the
number of platelet suspension, number of erythrocyte suspension and incidence of acute
graft versus disease after HSCT.
Material and methods
Patients who had allogeneic stem cell transplantation at our center between 01.01.2011
and 01.01.2022 were retrospectively analyzed. Patients were divided into 2 groups
as those who received and did not receive G-CSF after transplantation.
Results
A total of 64 patients were included. While 32 patients were given post-HSCT G-CSF
support, the other 32 patients were not given. Neutrophil engraftment time and length
of hospital stay were shorter in the group receiving G-CSF (p < 0.05). Platelet engraftment
time was shorter in the group that did not receive G-CSF (p < 0.05). The incidence
of acute GVHD of the patients in group 1 tended to be higher than the patients in
group 2 (40.6 % vs 15.6 %, p = 0.052). Post-HSCT platelet suspension was less in the
group that did not receive G-CSF, but this difference was not statistically significant
(p = 0.173).
Conclusion
While the positive effect of post HSCT G-CSF use on duration of neutrophil engraftment
and hospitalization is evident, its effects on platelet engraftment need to be investigated.
Keywords
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Article info
Publication history
Published online: June 06, 2022
Accepted:
June 4,
2022
Received in revised form:
May 25,
2022
Received:
January 2,
2022
Identification
Copyright
© 2022 Elsevier Ltd. All rights reserved.
