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The D-dimer reference intervals in healty term newborns

  • Zamin İbrahim Khalilov
    Affiliations
    Ankara Yıldırım Beyazıt University Medical Faculty, Department of Pediatrics, Ankara city Hospital, Ankara, Turkey
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  • Author Footnotes
    1 Department of Pediatrics, Division of Neonatology, Ankara Yıldırım Beyazıt University Medical Faculty, Yenimahalle Training and Research Hospital Ankara, Turkey
    Ayşe Ünsal
    Footnotes
    1 Department of Pediatrics, Division of Neonatology, Ankara Yıldırım Beyazıt University Medical Faculty, Yenimahalle Training and Research Hospital Ankara, Turkey
    Affiliations
    Yıldırım Beyazıt University Medical Faculty, Yenimahalle Training and Research Hospital Ankara, Turkey
    Search for articles by this author
  • Nilgün Altuntaş
    Correspondence
    Correspondence to: Ankara Yıldırım Beyazıt University Medical Faculty, Department of Pediatrics, Division of Neonatology, Ankara City Hospital, Postal Code: 06760, Ankara, Turkey.
    Affiliations
    Ankara Yıldırım Beyazıt University Medical Faculty, Department of Pediatrics, Division of neonatology, Ankara city Hospital, Ankara, Turkey
    Search for articles by this author
  • Author Footnotes
    1 Department of Pediatrics, Division of Neonatology, Ankara Yıldırım Beyazıt University Medical Faculty, Yenimahalle Training and Research Hospital Ankara, Turkey

      Abstract

      Objective

      To determine the D-dimer reference intervals in the neonatal period.

      Materials and methods

      The research had been carried out in the obstetrics and gynecology clinic and neonatal outpatient clinic of a third level hospital. Healthy term newborns aged between 1 and 28 days were enrolled in the study. Venous blood samples were collected from peripheral veins in all babies and D-dimer, prothrombin time, activated partial thromboplastin time and platelet counts were measured. Reference intervals for D-dimer in the neonatal period were determined using 2.5th and 97.5th percentile values.

      Results

      A hundred and thirty four newborns (71 boys, 63 girls) were enrolled in the study. Mean D-dimer levels of infants aged 1–28 days was 1.74 ± 1.88 mg/L (reference range; 0.25–2.81 mg/L). D-dimer levels were between 2.44 and 2.45 mg/L, 1.71–1.76 mg/L, 1.26–0.89 mg/L and 0.88–0.66 mg/L in the first, second, thirth and fourth week of life,respectively. D-dimer values inversely correlated with postnatal age (r:−0.3, p < 0.001). However, it remained above adult levels even in the last week. There was no statistically significant difference between the D-dimer levels of girls (1.93 ± 2.06 mg/L) and of boys (1.57 ± 1.71 mg/L).

      Discussion

      In this study, D-dimer levels in the neonatal period were found to be higher than adult levels stated in the literature. D-dimer levels gradually decreased overtime in the first month. It would be appropriate to use age-specific reference values in the evaluation of D dimer levels in the neonatal period.

      Keywords

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