Highlights
- •Human gemykibivirus-2 (HuGkV-2) is an emerging virus discovered by metagenomics.
- •HuGkV-2 DNA prevalence was estimated in Brazilian blood donors from three regions (Amazon, Central-West and South).
- •The Higher ighest HuGkV-2 DNA prevalence was estimated in the Brazilian Amazon,
- •More studies are needed to examine HuGkV-2 clinical significance and, transmission routes
Abstract
Human gemykibivirus-2 (HuGkV-2) belonging to the Gemykibivirus genus (Genomoviridae
family) is an emerging DNA virus which has been described as a component of the virome
of a wide variety of samples including clinical ones. So far, the HuGkV-2 DNA prevalence
in the human population as well as its clinical impact are completely unknown. The
objective of this study was to investigate the HuGkV-2 DNA prevalence among Brazilian
healthy blood donors from three different geographic regions. A total of 450 blood
samples were screened for HuGkV-2 DNA (150 samples were from the Brazilian Amazon,
150 from Midwest Brazil and 150 from South Brazil). The overall HuGkV-2 DNA prevalence
was 7.8 %. Considering the examined regions, the highest prevalence was observed in
the Brazilian Amazon (city of Macapa, state of Amapa), 15.3 %, followed by the Midwest
Brazil (city of Brasilia, Federal District) (6.0 %) and South Brazil (city of Santa
Maria, Rio Grande do Sul State) (2.0 %). This study gives preliminary insights on
the molecular prevalence of HuGkV-2 DNA among Brazilian blood donors, highlighting
that the highest HuGkV-2 prevalence was recorded in the Brazilian Amazon. However,
more studies regarding the prevalence, transmission routes and any possible clinical
effects appear to be crucial in order to understand the impact of this emerging viral
agent.
Keywords
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Article info
Publication history
Published online: July 26, 2022
Accepted:
July 25,
2022
Received in revised form:
July 6,
2022
Received:
May 4,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Ltd. All rights reserved.
