Abstract
Background
The purpose of this study was to analyze the application of individual factors, blood
cell related indicators, and blood donation frequency in predicting the risk of iron
deficiency of plateletpheresis donors.
Methods
A total of 801 plateletpheresis donors were included in this study. The relationship
between risk factors and iron deficiency was retrospectively analyzed by univariate
analysis and logistic regression analysis. The application of Hb, MCHC, RDW-CV and
blood donation frequency combined prediction of iron deficiency risk among plateletpheresis
donors was evaluated.
Result
The rate of iron deficiency in this study was 31.5 % (241/766). The age, gender (the
ratio of male donors), red blood cell related indicators, blood donation frequency
were statistically different between the normal and iron deficiency group (all P < 0.05). Age, gender, the reciprocal of Hb and MCHC, RDW-CV, total number of blood
donation and number of plateletpheresis donation in the past year, these indicators
to predict the risk of iron deficiency area under the curve (AUC) were 0.558, 0.672,
0.785, 0.717, 0.599, 0.621, 0.646, respectively. The AUC of these indicators combined
to predict the risk of iron deficiency was 0.877, higher than all single indicators.
The sensitivity and specificity of these indicators combined in prediction of iron
deficiency were 88.89 % and 81.57 %, respectively.
Conclusion
Age, gender, the reciprocal of Hb and MCHC, RDV-CV, blood donation frequency are associated
with the risk of iron deficiency in plateletpheresis donors. The combination of these
indicators has high value in predicting the risk of iron deficiency.
Keywords
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Article info
Publication history
Published online: August 08, 2022
Accepted:
August 7,
2022
Received in revised form:
July 28,
2022
Received:
February 15,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Ltd. All rights reserved.
