Abstract
Background
The immunogenicity of a blood group antigen is a measure of its likelihood of inducing
alloantibodies. Although the immunogenicity of blood group antigens has been analyzed
in Caucasian populations, immunogenicity to date has not been analyzed in Asian subjects.
The present study therefore evaluated the relative immunogenicity of blood group antigens
in a Korean population.
Study design and methods
All available data of unexpected antibody identification tests performed at Asan Medical
Center between 1997 and 2021 were analyzed. The relative immunogenicity of a blood
group antigen relative to K antigen was calculated based on relative numbers of alloantibodies
and the probabilities of antigen-negative recipients receiving antigen-positive RBC
units.
Results
A total of 3898 antibody identification results were included, with 1632 (41.9 %)
from male patients. The ranking of antigen immunogenicity was: E > c > e > C > K > Jk(a)
> Lu(a) > S > Fy(a) > Fy(b) > Jk(b) > Di(b) > Di(a) in the total population and E > c
> e > C > Jk(a) > Fy(a) > Fy(b) > S > K > Lu(a) > Jk(b) > Di(b) > Di(a) in male patients.
Discussion
The rank order of immunogenicity for blood group antigens in this study provides information
about relative immunogenecity in Koreans. These findings also provide supporting evidence
regarding antigen selection for extended antigen-matched transfusions in recipients
of multiple transfusions.
Keywords
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Article info
Publication history
Published online: October 25, 2022
Accepted:
October 22,
2022
Received in revised form:
September 25,
2022
Received:
May 18,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Ltd. All rights reserved.