Abstract
Background
The immunogenicity of a blood group antigen is a measure of its likelihood of inducing
alloantibodies. Although the immunogenicity of blood group antigens has been analyzed
in Caucasian populations, immunogenicity to date has not been analyzed in Asian subjects.
The present study therefore evaluated the relative immunogenicity of blood group antigens
in a Korean population.
Study design and methods
All available data of unexpected antibody identification tests performed at Asan Medical
Center between 1997 and 2021 were analyzed. The relative immunogenicity of a blood
group antigen relative to K antigen was calculated based on relative numbers of alloantibodies
and the probabilities of antigen-negative recipients receiving antigen-positive RBC
units.
Results
A total of 3898 antibody identification results were included, with 1632 (41.9 %)
from male patients. The ranking of antigen immunogenicity was: E > c > e > C > K > Jk(a)
> Lu(a) > S > Fy(a) > Fy(b) > Jk(b) > Di(b) > Di(a) in the total population and E > c
> e > C > Jk(a) > Fy(a) > Fy(b) > S > K > Lu(a) > Jk(b) > Di(b) > Di(a) in male patients.
Discussion
The rank order of immunogenicity for blood group antigens in this study provides information
about relative immunogenecity in Koreans. These findings also provide supporting evidence
regarding antigen selection for extended antigen-matched transfusions in recipients
of multiple transfusions.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Transfusion and Apheresis ScienceAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
Cohn C.S., Delaney M., Johnson S.T., Katz L.M. Technical manual. 20th ed. Bethesda (MD): American Association of Blood Banks; 2020.
- Pre-transfusion phenotype matching for sickle cell disease patients.Transfusion. 2004; 44: 619-620
- Phenotype matching of donor red blood cell units for nonalloimmunized sickle cell disease patients: a survey of 1182 North American laboratories.Arch Pathol Lab Med. 2005; 129: 190-193
- Clinical outcome of transfusions with extended red blood cell matching in β-thalassemia patients: a single-center experience.Transfus Apher Sci. 2019; 58: 65-71
- Red blood cell antigen genotype analysis for 9087 Asian, Asian American, and Native American blood donors.Transfusion. 2015; 55: 2369-2375
- A critique of the theoretical hazard of inter vs. intra-racial transfusion.Transfusion. 1961; 1: 233-238
- Immunogenicity of blood group antigens: a mathematical model corrected for antibody evanescence with exclusion of naturally occurring and pregnancy-related antibodies.Blood. 2009; 114: 4279-4282
- Estimating the immunogenicity of blood group antigens: a modified calculation that corrects for transfusion exposures.Br J Haematol. 2016; 175: 154-160
- Race/ethnicity affects the probability of finding an HLA-A, -B, -C and -DRB1 allele-matched unrelated donor and likelihood of subsequent transplant utilization.Bone Marrow Transpl. 2013; 48: 346-350
- Relative immunogenicity of Fya and K antigens in a Caucasian population, based on HLA class II restriction analysis.Transfusion. 2006; 46: 1328-1333
- Genotyping of 22 blood group antigen polymorphisms and establishing a national recipient registry in the Korean population.Ann Hematol. 2016; 95: 985-991
- Frequency of red blood cell antigens according to parent ethnicity in Korea using molecular typing.Ann Lab Med. 2018; 38: 599-603
- Blood group antigen and phenotype prevalence in the Korean population compared to other ethnic populations and its association with RBC alloantibody frequency.Transfus Med. 2019; 29: 415-422
- Incidence and persistence of anti-Kell after transfusion of Kell-positive blood.Beitr Infus Transfus. 1994; 32: 175-178
- The frequency of formation of Kell antibodies in recipients of Kell-positive blood.in: Videbaek A.A. Neumark E. Schubothe H. Bernard J. Proceedings of the sixth congress of the european society for haematology. S. Karger, Base, Switzerland1957: 754-758
Reid, M.E., Lomas-Francis, C., Olsson, M.L.2012. The blood group antigen factsBook. 3rd ed. Elsevier.
Article info
Publication history
Published online: October 25, 2022
Accepted:
October 22,
2022
Received in revised form:
September 25,
2022
Received:
May 18,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Ltd. All rights reserved.
