Analysis and clinical significance of peripheral blood routine changes of platelet donors with ultra-high frequency donation

  • Xin Zhao
    Correspondence to: Hainan Provincial Blood Center, 16 Meisu Road, Haikou 570311, Hainan Province, China.
    Department of Blood Examination and Collection, Hainan Provincial Blood Center, Haikou 570311, Hainan Province, China
    Search for articles by this author
  • Haoyi Qin
    Department of Blood Examination and Collection, Hainan Provincial Blood Center, Haikou 570311, Hainan Province, China
    Search for articles by this author
  • Wenhao Chen
    Department of Blood Examination and Collection, Hainan Provincial Blood Center, Haikou 570311, Hainan Province, China
    Search for articles by this author
  • Xiujuan Dong
    Correspondence to: Hainan Women and Children’s Medical Center, Changbin Road, Haikou 570312, Hainan Province, China.
    Department of Hematology Oncology, Hainan Women and Children’s Medical Center, Haikou 570312, Hainan Province, China
    Search for articles by this author
Published:November 18, 2022DOI:



      Increasing platelet donation frequency has become an important way to meet the growing clinical platelet need. Accordingly, the problem of whether the increase in platelet donation times will have an adverse effect on the health of donors has attracted more and more attention, and become an important factor affecting the donor enthusiasm and the safety of blood collection and supply.


      Eleven ultra-high frequency platelet donors who donated more than or equal to 20 times in 2021 were selected, and the main peripheral blood routine indicators of hemoglobin, platelet and hematocrit were analyzed.


      The above indicators of all donors fluctuated with the increase of donation times. Among them, older donors (≥50 years old) exhibited a significant downward trend in the above three indicators, and one young donor showed a downward trend in hemoglobin and hematocrit indicators. While the other donors showed the relatively stable performance of the above indicators.


      The effect of ultra-high frequency platelet donation on the main peripheral blood indexes of donors shows obvious age compliance, that is, the potential harm to ultra-high frequency donors older than 50 years is significantly greater than that of donors of other ages. Older platelet donors should be cautious about ultra-high frequency donations to avoid adverse health hazards. Meanwhile, the work will provide technical reference for the more scientific and efficient development of the platelet harvesting work and the establishment of the clinical blood supply system for related patients.


      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to Transfusion and Apheresis Science
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Wood L.
        • Jogessar V.
        • Ward P.
        • Jacobs P.
        Estimation and predictive use of the corrected count increment--a proposed clinical guideline.
        Transfus Apher Sci. 2005; 32: 117-124
        • Garraud O.
        • Cognasse F.
        • Tissot J.D.
        • Chavarin P.
        • Laperche S.
        • Morel P.
        • Lefrere J.J.
        • Pozzetto B.
        • Lozano M.
        • Blumberg N.
        • Osselaer J.C.
        Improving platelet transfusion safety: biomedical and technical considerations.
        Blood Transfus. 2016; 14: 109-122
        • Marwaha N.
        • Sharma R.R.
        Consensus and controversies in platelet transfusion.
        Transfus Apher Sci. 2009; 41: 127-133
        • Gil-Betacur A.
        • Mantilla-Gutiérrez C.Y.
        • Cardona-Arias J.A.
        Effect of plateletpheresis on hematocrit, hemoglobin and erythrocyte count: meta-analysis 1980–2018.
        Sci Rep. 2019; 9: 19770
        • Zhou Q.
        • Yu X.
        • Cai Y.
        • Liu L.
        Changes in pre- and post-donation platelet function in plateletpheresis donors.
        Transfus Clin Et Biol. 2017; 24: 417-421
        • Baart A.M.
        • van den Hurk K.
        • de Kort W.L.A.M.
        Minimum donation intervals should be reconsidered to decrease low hemoglobin deferral in whole blood donors: an observational study.
        Transfusion. 2015; 55: 2641-2644
        • Lazarus E.F.
        • Browning J.
        • Norman J.
        • Oblitas J.
        • Leitman S.F.
        Sustained decreases in platelet count associated with multiple, regular plateletpheresis donations.
        Transfusion. 2001; 41: 756-761
        • Gyongyossy-Issa M.I.C.
        • Miranda J.
        • Devine D.V.
        Generation of reticulated platelets in responseto whole blood donation or plateletpheresis.
        Transfusion. 2001; 41: 1234-1240
        • Cheng X.
        • Ma L.
        • Jiang N.
        • Li J.
        • Niu T.
        • Liu T.
        • Jia Y.
        Analysis on frequent plateletphoresis donors' platelet count, thrombopoietin and platelet derived growth factor concentration.
        Chin J Blood Transfus. 2016; 29: 385-387
        • Su R.J.
        • Li K.
        • Yang M.
        • Zhang X.B.
        • Tsang K.S.
        • Fok T.F.
        • Li C.K.
        • Yuen P.M.
        Platelet-derived growth factor enhances ex vivo expansion of megakaryocytic progenitors from human cord blood.
        Bone Marrow Transplant. 2001; 27: 1075-1080
        • Chinigi S.P.
        • Kaur G.
        • Kaur P.
        • Tahlan A.
        • Bedi R.K.
        • Mittal K.
        • Sood T.
        Assessment of serum iron stores in regular plateletpheresis donors.
        Transfus Apher Sci. 2022; 61: 103291-103297
        • Spencer B.R.
        • Haynes J.M.
        • Notari E.P.
        • Stramer S.L.
        Prevalence, risk factors, and ferritin testing to mitigate iron depletion in male plateletpheresis donors.
        Transfusion. 2020; 60: 759-768