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Letter to the editor|Articles in Press, 103637

Evidence for adverse effects by G-CSF in some acute lymphoblastic leukemias

  • Author Footnotes
    1 Department of Pathology and Clinical Laboratories, University of Michigan, Fellow Suite 35–1463-16, 2800 Plymouth Road, Building 35, Ann Arbor, MI USA 48109–2800
    Justin Kelley
    Footnotes
    1 Department of Pathology and Clinical Laboratories, University of Michigan, Fellow Suite 35–1463-16, 2800 Plymouth Road, Building 35, Ann Arbor, MI USA 48109–2800
    Affiliations
    Department of Pathology, Michigan Medicine-University of Michigan, Ann Arbor, MI, USA
    Search for articles by this author
  • Laura Cooling
    Correspondence
    Correspondence to: University of Michigan Hospitals, 2F222-UH Blood Bank, 1500 East Medical Center Drive, Ann Arbor, MI USA.
    Affiliations
    Department of Pathology, Michigan Medicine-University of Michigan, Ann Arbor, MI, USA
    Search for articles by this author
  • Author Footnotes
    1 Department of Pathology and Clinical Laboratories, University of Michigan, Fellow Suite 35–1463-16, 2800 Plymouth Road, Building 35, Ann Arbor, MI USA 48109–2800
Published:December 19, 2022DOI:https://doi.org/10.1016/j.transci.2022.103637
Evidence for adverse effects by G-CSF in some acute lymphoblastic leukemias
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      We read with interest the recent article by Tekgunduz and colleagues ‶The effect of granulocyte colony-stimulating factors on survival parameters in pediatric patients with acute lymphoblastic leukemia: a retrospective study″ [
      • Tekgunduz S.A.
      • Aycicek A.
      • Bayram C.
      • Uysalol E.P.
      • Akici F.
      • Ozdemir G.N.
      The effect of granulocyte-colony-stimulating factors on survival parameters in pediatric patients with acute lymphoblastic leukemia: a retrospective study.
      Transf Aph Sci. 2022; 61103366https://doi.org/10.1016/j.transci.2022.103366
      ]. Although therapeutic granulocyte-colony stimulating factor (G-CSF) is effective in reducing neutropenia and infection risks following chemotherapy, prophylactic G-CSF use can increase the risk of treatment-related myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). A link between G-CSF and AML is well established in patients with congenital neutropenia, who require long-term G-CSF support [
      • Vandenberghe P.
      • Beel K.
      Severe congenital neutropenia, a genetically heterogenous disease group with an increased risk of AML/MDS.
      Pediatr Rep. 2011; 3https://doi.org/10.4081/pr.2011.s2.e9
      ]. More recent studies have demonstrated a small measurable risk of AML and MDS due to limited prophylactic G-CSF exposure in non-Hodgkin lymphoma and breast cancer patients [
      • Calip G.S.
      • Moran K.M.
      • Sweiss K.I.
      • Patel P.R.
      • Wu Z.
      • Adimadhyam S.
      • et al.
      Myelodysplastic syndrome and acute myeloid leukemia after receipt of granulocyte colony-stimulating factors in older patients with non-Hodgkin lymphoma.
      Cancer. 2019; 125: 1143-1154https://doi.org/10.1002/cncr.31914
      ,
      • Calip G.S.
      • Malmgren J.A.
      • Lee W.-J.
      • Schwartz S.M.
      • Kaplan H.G.
      Myelodysplastic syndrome and acute myeloid leukemia following adjuvant chemotherapy with and without granulocyte colony-stimulating factors for breast cancer.
      Breast Cancer Res Treat. 2015; 154: 133-143https://doi.org/10.1007/s10549-015-3590-1
      ]. More importantly, prophylactic G-CSF in pediatric AML patients is an established risk factor for relapse and is no longer considered standard of care [
      • Lohmann D.J.A.
      • Asdahl P.H.
      • Abrahamsson J.
      • Ha S.-Y.
      • Jonsson O.G.
      • Daspers G.J.L.
      • et al.
      Use of granulocyte colony-stimulating factor and risk of relapse in pediatric patients treated for acute myeloid leukemia according to NOPHO-AML 2004 and DB AML-01.
      Pedia Blood Cancer. 2019; 66e27701https://doi.org/10.1002/pgc.27701
      ,
      • Creutzig U.
      • van den Heuvel-Eibrink M.M.
      • Gibson B.
      • Dworzak M.N.
      • Adachi S.
      • de Bont E.
      • et al.
      Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel.
      Blood. 2012; 120: 3187-3205https://doi.org/10.1182/blood-2012-03-362608
      ].

      Keywords

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        View in Article
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        View in Article
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      Article info

      Publication history

      Published online: December 19, 2022
      Accepted: December 16, 2022
      Received: December 2, 2022

      Publication stage

      In Press Journal Pre-Proof

      Identification

      DOI: https://doi.org/10.1016/j.transci.2022.103637

      Copyright

      © 2022 Elsevier Ltd. All rights reserved.

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