Abstract
Platelet transfusions decreased the risk of morbidity and mortality secondary to thrombocytopenia.
This therapy not only ameliorates platelet loss in bleeding patients,but also those
with acquired dysfunction of platelets. The current standard of practice worldwide
is to provide room temperature platelets (RTPs); however, there are many disadvantages
to the use of RTPs such that alternative approaches have been explored. One potential
approach is the integration and use of cold stored platelets (CSP), which are platelets
stored at 1–6 °C, in clinical settings. CSP research studies show equivalent hemostasis
and platelet dysfunction restoration compared to RTPs. In addition, publications have
demonstrated advantages of CSP such as reduced bacterial contamination and wastage.
Despite its benefits, the production of CSP by blood centers (BCs) and uptake and
use of CSP by hospitals has remained relatively low. This review highlights the rationale
for CSP production and strategies for overcoming the implementation challenges faced
by BCs based on a literature review.Experiences of Consortium for Blood Availability
members to integrate CSP in their BCs and clinical practices by providing variance
applications are reviewed in this paper. Also, demonstrated in this manuscript are
the current indications and opportunities for CSP utilization by healthcare providers.
Keywords
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Article info
Publication history
Published online: January 04, 2023
Accepted:
January 3,
2023
Received in revised form:
December 23,
2022
Received:
April 16,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Published by Elsevier Ltd.
