Abstract
Background
In this retrospective study, we evaluated the effect of ferritin levels on the outcomes
of autologous stem cell transplantation in patients with MM or lymphoma.
Methods
In this study, 170 patients with measured ferritin levels within one month before
transplantation who underwent ASCT with the diagnosis of MM or lymphoma were evaluated.
The cut-off value of ferritin was determined as 500 ng/mL to evaluate the transplant
outcomes in both groups. The hematological recovery status/duration, febrile neutropenia
rate, hospitalization time, transplant-related mortality (TRM) in the first 100 days,
and OS were evaluated according to the ferritin level
Results
Of all patients, 105 (61,8%) were diagnosed with MM and 65 (38.2%) with lymphoma.
Ferritin levels had no statistically significant effect on the engraftment status/times,
the febrile neutropenia rates, and hospitalization times of both lymphoma and myeloma
patients (p > .05). Ferritin level was not significantly associated with TRM in MM
(p = .224). However, in lymphoma, ferritin level was significantly associated with
TRM (33.3% for ferritin level ≥500 ng/L vs. 5.3% for ferritin level ng/mL, p = .005).
There was no statistically significant correlation between ferritin value and OS in
MM group [ferritin level ≥ 500 ng/L: 39.9 months (95% CI: 33.7–46.1) and ferritin
level 500 ng/mL: 39.4 months (95% CI: 36.5–42.2), p = .446]. Ferritin level was significantly
associated with OS in patients with lymphoma [ferritin level ≥ 500 ng/L: 22.1 months
95% CI: 14.7–29.5), ferritin level 500 ng/mL: 27.3 months (95% CI: 22.4–32.2), p = .038]
Conclusion
High ferritin level is important prognostic factor on survival after ASCT in patients
with lymphoma.
Keywords
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Article info
Publication history
Published online: February 16, 2023
Accepted:
February 9,
2023
Received in revised form:
February 3,
2023
Received:
December 26,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Elsevier Ltd. All rights reserved.
