Abstract
Acute hemolytic transfusion reaction following ABO-incompatible platelet transfusion:
two case reports
An ideal platelet transfusion should provide ABO identical platelet concentrate, and
cross match compatibility is not routinely performed in the standard practices. However,
ABO non identical platelet transfusions are not uncommon with the limited resources
and short shelf life of platelet concentrate. Though rare, acute hemolytic transfusion
reaction (AHTR) may occur following minor ABO-incompatible platelet transfusion. Here,
we report two cases of thrombocytopenic patients (one child and one adult) type as
Group B RhD positive and received Group O RhD positive platelet transfusions. Both
patients experienced an AHTR evidenced by a drop in hemoglobin level, spherocytosis
and small agglutinations on the blood film, and positive direct Coombs test. They
were treated symptomatically, recovered and discharged well post-event without any
morbidity. No anti-B isohemagglutinins titer were done to confirm the high titer of
the antibody in the platelet donors. Our cases highlighted the importance of ABO-compatible
platelet transfusion, especially to children and those vigilant groups of patients.
Keywords
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Article info
Publication history
Published online: February 15, 2023
Accepted:
February 13,
2023
Received in revised form:
January 30,
2023
Received:
November 9,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Elsevier Ltd. All rights reserved.
